عنوان

Reactive drug metabolites /

(Number (ISBN

3527330852 (hbk. : alk. paper)

(Number (ISBN

9783527330850 (hbk. : alk. paper)

Erroneous ISBN

3527655743 (eBook)

Erroneous ISBN

3527655743 (oBook)

Erroneous ISBN

3527655751 (mobi)

Erroneous ISBN

9783527655748 (eBook)

Erroneous ISBN

9783527655748 (oBook)

Erroneous ISBN

9783527655755 (mobi)

Erroneous ISBN

9783527655779 (ePDF)

Country Code

bnb

Number

b433375

Title Proper

Reactive drug metabolites /

General Material Designation

[Book]

First Statement of Responsibility

Amit S. Kalgutkar ... [et al.]

Place of Publication, Distribution, etc.

Weinheim :

Name of Publisher, Distributor, etc.

Wiley-VCH,

Date of Publication, Distribution, etc.

c2012

Specific Material Designation and Extent of Item

xvi, 385 p. :

Other Physical Details

ill. ;

Dimensions

25 cm

Series Title

Methods and principles in medicinal chemistry ;

Volume Designation

v. 55

Text of Note

Includes bibliographical references and index

Text of Note

Origin and historical perspective on reactive metabolites -- Role of reactive metabolites in genotoxicity -- Bioactivation and inactivation of cytochrome P450 and other drug-metabolizing enzymes -- Role of reactive metabolites in drug-induced toxicity - the tale of acetaminophen, halothane, hydralazine, and tienilic acid -- Pathways of reactive metabolite formation with toxicophores/-structural alerts -- Intrinsically electrophilic compounds as a liability in drug discovery -- Role of reactive metabolites in pharmacological action -- Retrospective analysis of structure-toxicity relationships of drugs -- Bioactivation and natural products -- Experimental approaches to reactive metabolite detection -- Case studies on eliminating/reducing reactive metabolite formation in drug discovery -- Structural alert and reactive metabolite analysis for the top 200 drugs in the US market by prescription -- Mitigating toxicity risks with affinity labeling drug candidates -- Dealing with reactive metabolite-positive compounds in drug discovery -- Managing IADRs - a risk-benefit analysis

0

Drugs-- Toxicology

Drug Discovery

Drug-Related Side Effects and Adverse Reactions

Pharmaceutical Preparations-- metabolism

Number

Edition

Class number

Book number

Class number

Class number

Book Number

Kalgutkar, Amit S.,1965-

Date of Transaction

20130604035729.0

Electronic name

[Book]

Y