The increasing burden of type 2 diabetes: magnitude, causes, and implications of the epidemic / Edward W. Gregg and Andrea K. Kriska -- Waging war on type 2 diabetes: primary prevention through exercise biology / Frank W. Booth, Manu V. Chakravarthy, and Matthew J. Laye -- Fatty acid uptake and insulin resistance / Arend Bonen ... [et al.] -- Lipid metabolism and insulin signaling / Jason R. Berggren, Leslie A. Consitt, and Joseph A. Houmard -- Metabolic inflexibility and insulin resistance / Bret Goodpaster and David E. Kelley -- Nutrient sensor links obesity with diabetes risk / Sarah Crunkhorn and Mary Elizabeth Patti -- Inflammation-induced insulin resistance in obesity: when immunity impacts on metabolic control / Phillip James White and André Marette -- Transcription factors regulating exercise adaptation / David Kitz Krämer and Anna Krook -- Exercise and calorie restriction use different mechanisms to improve insulin sensitivity / Gregory D. Cartee -- Mitochondrial oxidative capacity and insulin resistance / Kevin R. Short -- Effects of acute exercise and exercise training on insulin action in skeletal muscle / Erik A. Richter and Jürgen F.P. Wojtaszewski -- Resistance exercise training and the management of diabetes / Jürgen F.P Wojtaszewski, Henriette Pilegaard, and Flemming Dela -- AMPK: the master switch for type 2 diabetes? / W.W. Winder and D.M Thomson -- Protein kinase C and insulin resistance / Carsten Schmitz-Peiffer -- Evidence for prescribing exercise as a therapy for treating of patients with type 2 diabetes / Sarah J. Lessard and John A. Hawley.