عنوان

Protein misfolding and cellular stress in disease and aging :

شابک

1607617560

شابک

9781607617563

شابک اشتباه

1607617552

شابک اشتباه

9781607617556

شماره

b753059

عنوان اصلي

Protein misfolding and cellular stress in disease and aging :

نام عام مواد

[Book]

ساير اطلاعات عنواني

concepts and protocols /

نام نخستين پديدآور

edited by Peter Bross and Niels Gregersen.

محل نشرو پخش و غیره

London :

نام ناشر، پخش کننده و غيره

Springer [distributor],

تاریخ نشرو بخش و غیره

2010.

نام خاص و کميت اثر

1 online resource (xi, 330 pages) :

ساير جزييات

illustrations

عنوان فروست

Methods in molecular biology,

عنوان فروست

Springer protocols

مشخصه جلد

648

شاپا ي ISSN فروست

1064-3745 ;

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Protein misfolding and cellular stress : an overview -- Protein aggregation diseases: toxicity of soluble prefibrillar aggregates and their clinical significance -- Consequences of stress in the secretary pathway : the ER stress response and its role in the metabolic syndrome -- What role does mitochondrial stress play in neurodegenerative diseases? -- Autophagy in disease -- Mitophagy and mitoptosis in disease processes -- Cellular stress and protein misfolding during aging -- Measuring consequences of protein misfolding and cellular stress using OMICS techniques -- Production of cells with targeted integration of gene variants of human ABC transporter for stable and regulated expression using the Flp recombinase system -- Stress response profiles in human fibroblasts exposed to heat shock or oxidative stress -- Examining ubiquitinated protein aggregates in tissue sections -- Determination of proteasomal activities -- Measurement of autophagy in cells and tissues -- Transcription factor sequestration by polyglutamine proteins -- Biological membranes as protein aggregation matrices and targets of amyloid toxicity -- Measurement of mitochondrial ROS production -- In vivo detection of oxidized proteins : a practical approach to tissue-derived mitochondria -- Measurement of oxidized/reduced glutathione ratio -- Determination of altered mitochondria ultrastructure by electron microscopy -- Assessing bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity -- A cellular viability assay to monitor drug toxicity -- Rescue of misfolded proteins and stabilization by small molecules.

بدون عنوان

0

متن يادداشت

How and why certain proteins misfold and how this misfolding is linked to many disease processes has become a well-documented topic of study. Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols moves beyond the basics to emphasize the molecular effects of protein misfolding at a cellular level, to delineate the impacts and cellular reactions that play a role in pathogenetic mechanisms, and to pinpoint possible manipulations and treatment strategies that can counteract, modify, or delay the consequences of misfolding. The volume begins with several concepts and approaches developed in the recent past including a connection to the research field of aging, where protein misfolding diseases have been equated to premature aging processes, and the book's coverage continues with detailed descriptions of protocols for relevant experimental approaches. Written in the highly successful Methods in Molecular Biology series format, protocols chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols aims to aid researchers in the field, as well as medical professionals and molecular biologists, in shaping and performing research related to this intriguing and vital subject.

منبع سفارش / آدرس اشتراک

Springer

شماره انبار

978-1-60761-755-6

عنوان

Protein misfolding and cellular stress in disease and aging.

شماره استاندارد بين المللي کتاب و موسيقي

9781607617556

موضوع مستند نشده

Pathology, Cellular.

موضوع مستند نشده

Protein folding.

موضوع مستند نشده

Proteins-- Pathophysiology.

موضوع مستند نشده

Aging.

موضوع مستند نشده

Amino Acids, Peptides, and Proteins

موضوع مستند نشده

Anatomy.

موضوع مستند نشده

Biochemical Phenomena.

موضوع مستند نشده

Biological Science Disciplines.

موضوع مستند نشده

Biophysical Phenomena.

موضوع مستند نشده

Cells.

موضوع مستند نشده

Chemical Phenomena.

موضوع مستند نشده

Chemicals and Drugs

موضوع مستند نشده

Disciplines and Occupations

موضوع مستند نشده

Growth and Development.

موضوع مستند نشده

Health Occupations.

موضوع مستند نشده

Laboratory Manuals

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Natural Science Disciplines.

موضوع مستند نشده

Pathology.

موضوع مستند نشده

Phenomena and Processes

موضوع مستند نشده

Physical Phenomena.

موضوع مستند نشده

Physiological Phenomena.

موضوع مستند نشده

Physiology.

موضوع مستند نشده

Protein Folding.

موضوع مستند نشده

Proteins.

موضوع مستند نشده

Publication Characteristics

موضوع مستند نشده

Publication Formats

موضوع مستند نشده

Animal Biochemistry.

موضوع مستند نشده

Health & Biological Sciences.

موضوع مستند نشده

Human Anatomy & Physiology.

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Pathology, Cellular.

موضوع مستند نشده

Pathology.

موضوع مستند نشده

Protein folding.

موضوع مستند نشده

PSF

موضوع مستند نشده

SCI049000

شماره

ويراست

شماره رده

شماره رده

مستند نام اشخاص تاييد نشده

Bross, Peter.

مستند نام اشخاص تاييد نشده

Gregersen, Niels.

تاريخ عمليات

20201204123725.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y