عنوان

Drug safety evaluation :

شابک

1607618494

شابک

9781607618492

شابک اشتباه

1603271864

شابک اشتباه

9781603271868

شماره

b742464

عنوان اصلي

Drug safety evaluation :

نام عام مواد

[Book]

ساير اطلاعات عنواني

methods and protocols /

نام نخستين پديدآور

edited by Jean-Charles Gautier.

محل نشرو پخش و غیره

New York :

نام ناشر، پخش کننده و غيره

Humana Press,

تاریخ نشرو بخش و غیره

©2011.

نام خاص و کميت اثر

1 online resource (xiii, 431 pages) :

ساير جزييات

illustrations

عنوان فروست

Methods in molecular biology ;

مشخصه جلد

v. 691

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Part I General Toxicology -- Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler -- Part II Pathology -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette and Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui and Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, and William M. Gallagher -- Part III Genetic Toxicology -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Part IV Safety Pharmacology -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe -- Part V Investig ativ e Toxicology -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves and Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, and Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha El Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, and Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek and Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- Part VI Screening Ass ays for Developmental Toxicity -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay -- Part VII Chemical Protein Adducts -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau -- One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau -- Part VIII Safety Biomarkers -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y.K. Lau, Stephen R. Pennington, and William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Gotz Schlotterbeck, Alfred Ross, Hans Senn, and Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y.K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington.

بدون عنوان

0

متن يادداشت

Non-clinical drug safety evaluation, the assessment of the safety profile of therapeutic agents through the conduct of laboratory studies in in vitro systems and in animals, is an essential step in the progress of new pharmaceuticals heading toward the ultimate goal of clinical trials and, eventually, approval. In Drug Safety Evaluation: Methods and Protocols, expert researchers detail a compendium of analytical technologies with a focus on clarity and applicability in real life laboratory practice. These meticulous contributions feature key topics such as acute to chronic general toxicity studies, histopathology studies, reproductive toxicity studies, genotoxicity studies, safety pharmacology studies, investigative toxicity studies, and safety biomarker studies. As a volume in the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Drug Safety Evaluation: Methods and Protocols serves as an ideal guide to this field, helpful to pharmaceutical scientists, toxicologists, biochemists, and molecular biologists as well as scientists from all other disciplines who wish to translate these thorough methods into their own work.

منبع سفارش / آدرس اشتراک

Springer

شماره انبار

978-1-60327-186-8

عنوان

Drug safety evaluation.

شماره استاندارد بين المللي کتاب و موسيقي

9781603271868

موضوع مستند نشده

Drugs-- Testing.

موضوع مستند نشده

Analytical, Diagnostic and Therapeutic Techniques and Equipment

موضوع مستند نشده

Disease.

موضوع مستند نشده

Drug Discovery.

موضوع مستند نشده

Drug Evaluation, Preclinical.

موضوع مستند نشده

Drug-Related Side Effects and Adverse Reactions.

موضوع مستند نشده

Evaluation Studies as Topic.

موضوع مستند نشده

Investigative Techniques

موضوع مستند نشده

Methods.

موضوع مستند نشده

Poisoning.

موضوع مستند نشده

Substance-Related Disorders.

موضوع مستند نشده

Toxicity Tests.

موضوع مستند نشده

Drugs-- Testing.

موضوع مستند نشده

MED071000

موضوع مستند نشده

MMG

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

مستند نام اشخاص تاييد نشده

Gautier, Jean-Charles.

تاريخ عمليات

20201204031041.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y