عنوان

Immunosuppressant analogs in neuroprotection /

شابک

1592593151

شابک

9781592593156

شابک اشتباه

0896039447

شابک اشتباه

9780896039445

شماره

b704243

عنوان اصلي

Immunosuppressant analogs in neuroprotection /

نام عام مواد

[Book]

نام نخستين پديدآور

edited by Cesario V. Borlongan, Ole Isacson, Paul R. Sanberg ; foreword by Solomon H. Snyder and Bahman Aghdasi.

محل نشرو پخش و غیره

Totowa, N.J. :

نام ناشر، پخش کننده و غيره

Humana Press,

تاریخ نشرو بخش و غیره

©2003.

نام خاص و کميت اثر

1 online resource (xxvii, 378 pages) :

ساير جزييات

illustrations (some color)

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

""Immunosuppressant Analogs in Neuroprotection""; ""Foreword""; ""Preface""; ""Contents""; ""Contributors""; ""Immunosuppressants, Neurologic, Disorders, and Neuroprotection""; ""1 Introduction: Immunosuppressants as Neuroprotective Agents""; ""Immunosuppressants and Parkinson's Disease""; ""2 Cyclosporin-Mediated Amelioration of Degeneration of Dopaminergic Neurons in Experimental Models of Parkinsonism""; ""3 Immunophilin Ligands and Dopamine Neurons""; ""4 Effects of Neuroimmunophilin Ligands on Parkinson�s Disease and Cognition""

متن يادداشت

""10 Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion""""11 Blockade of Late-Onset Reduction of Muscarinic Acetylcholine Receptors by Immunosuppressants in Forebrain Ischemia""; ""12 The Role of Immunophilins in Focal Cerebral Ischemia Evidence of Neuroprotection by FK506""; ""13 Immunosuppressants in Traumatic Brain Injury""; ""Immunosuppressants and Spinal Cord Injury""; ""14 Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Rats""

متن يادداشت

""15 Axonal Regeneration in Cyclosporin A-Treated Rats Submitted to Transverse Section of the Spinal Cord""""Immunosuppressants and Sciatic Nerve Injury""; ""16 Neuroimmunophilin Ligands Accelerate and Promote Nerve Regeneration in the Rat Peripheral Nerve and Spinal Cord Role of the Steroid Receptor�FKBP52 Complex""; ""17 Neuroimmunophilin Ligands Stimulate Recovery of Injured Sciatic Nerves""; ""Immunosuppressants and Other Disorders of the Central Nervous System""

متن يادداشت

""18 Cyclosporin A Prolongs Survival of SOD1 Mutant Mice and Implicates Mitochondrial Permeability Transition in Amyotrophic Lateral Sclerosis""""19 Psychological Effects of Cyclosporin A""; ""Index""

متن يادداشت

""5 Improved Survival of Grafted Dopamine Neurons by Calcineurin Inhibitors""""6 Possible Mechanisms Underlying the Protective Action of Immunosuppressants Against Parkinson�s Disease""; ""Immunosuppressants and Other Age-Related Disorders""; ""7 Immunosuppressants and Alzheimer�s Disease""; ""8 Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunction""; ""Immunosuppressants, Stroke, and Traumatic Brain Injury""; ""9 Cyclosporin A Protects Mitochondria in an In Vitro Model of Hypoxia/Reperfusion Injury""

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

متن يادداشت

In recent years there has been a growing recognition that such widely used immunosuppressant drugs as cyclosporin and FK-506 and their analogs-the neuroimmunophilins-possess significant neurotrophic and neuroprotective properties in addition to their beneficial effects for transplant patients. In Immunosuppressant Analogs in Neuroprotection, pioneers in the field and leading neuroscientists and clinicians working with these drugs survey the most recent scientific evidence showing how they evolved from being purely immunosuppressant "drugs" to neuroprotective "agents." These authorities focus on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. They discuss their efficacy and mechanisms of action in vitro and in vivo; using these models of CNS disease, they report laboratory studies with compelling clinical indications for Alzheimer's disease, Huntington's disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction. They also present novel hypotheses on the mechanisms of neuroprotection, ranging from the blockade of mitochondrial permeability transition pores to free radical scavenging to the inhibition of calcineurin. Authoritative and cutting-edge, Immunosuppressant Analogs in Neuroprotection demonstrates that CsA, FK-506, and the immunophilins exert neuroprotective effects on their own and will serve well as a new breed of neuroprotective agents for the treatment of neurological disorders.

متن يادداشت

Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

عنوان

Immunosuppressant analogs in neuroprotection.

موضوع مستند نشده

Immunosuppressive agents.

موضوع مستند نشده

Nervous system-- Degeneration-- Chemoprevention.

موضوع مستند نشده

Nervous system-- Regeneration.

موضوع مستند نشده

Neuropratective agents.

موضوع مستند نشده

Immunophilins.

موضوع مستند نشده

Immunosuppressive Agents-- therapeutic use.

موضوع مستند نشده

Neuroprotective Agents-- pharmacology.

موضوع مستند نشده

HEALTH & FITNESS-- Diseases-- Nervous System (incl. Brain)

موضوع مستند نشده

Immunosuppressive agents.

موضوع مستند نشده

Immunsuppressivum

موضوع مستند نشده

MEDICAL-- Neurology.

موضوع مستند نشده

Nervendegeneration

موضوع مستند نشده

Nervous system-- Degeneration-- Chemoprevention.

موضوع مستند نشده

Nervous system-- Regeneration.

موضوع مستند نشده

HEA-- 039110

موضوع مستند نشده

MED-- 056000

موضوع مستند نشده

MJN

موضوع مستند نشده

MKJ

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

شماره رده

شماره رده

نشانه اثر

کد سيستم

مستند نام اشخاص تاييد نشده

Borlongan, Cesario V.

مستند نام اشخاص تاييد نشده

Isacson, Ole.

مستند نام اشخاص تاييد نشده

Sanberg, Paul R.

تاريخ عمليات

20201207194249.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y