Atherosclerosis: signal transduction by oxygen and nitrogen / Jonathan M. Hill, Ilsa L. Rovira, and Toren Finkel -- NF-kB: a key signaling pathway in asthma / Stewart J. Levine -- Molecular mechanisms of cancer / Akrit Sodhi, Silvia Montaner, and J. Silvio Gutkind -- Apoptotic pathways in cancer progression and treatment / Joya Chandra and Scott H. Kaufmann -- Molecular and cellular aspects of insulin resistance: implications for diabetes / Derek Le Roith, Michael J. Quon, and Yehiel Zick -- Dysfunction of G protein-regulated pathways and endocrine diseases / William F. Simonds -- Bacterial regulation of the cytoskeleton / Jeremy W. Peck, Dora C. Stylianou, and Peter D. Burbelo -- Bacterial toxins and diarrhea / Walter A. Patton, Joel Moss, and Martha Vaughan -- Molecular basis of severe combined immunodeficiency: lessons from cytokine signaling pathways / Roberta Visconti, Fabio Candotti, and John J. O'Shea -- Mast cell-related diseases: genetics, signaling pathways, and novel therapies / Michael A. Beaven and Thomas R. Hundley -- Rheumatology and signal transduction / Keith M. Hull and Daniel l. Kastner -- Molecular mechanisms of neurodegenerative disorders / Benjamin Wolozin -- Neurotropic signaling in mood disorders / Jing Du, Todd D. Gould, and Husseini K. Manji -- Inhibiting signaling pathways through rational drug design / James N. Topper and Neill A. Giese.