Resistance mechanisms to antimetabolites -- Resistance to antitumor alkylating agents and cisplatin -- The MDR genes -- Topoisomerase genes and resistance to topoisomerase inhibitors -- Genes that modulate apoptosis: major determinatns of drug resistance -- Clinical implications of drug resistance -- The reversal of multidrug resistance -- Effect of dose and schedule on chemotherapeutic drug resistance -- Circumvention of drug resistance by high-dose chemotherapy in solid tumors -- Enhancing drug effectiveness by gene transfer.
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Drug resistance in cancer cells.
Antineoplastic Agents-- therapeutic use.
Drug Resistance, Neoplasm-- physiology.
Antinéoplasiques-- usage thérapeutique.
Cellules cancéreuses-- Résistance aux médicaments.
Chemotherapie.
Drug resistance in cancer cells.
Geneesmiddelenresistentie.
Krebs (Medizin)
Résistance aux médicaments antinéoplasiques-- Physiologie.