Physiology and pathophysiology of the HPA axis -- Etiologies of Cushing's syndrome -- Pathogenesis of corticotropic tumors -- Pathogenesis of adrenocortical tumors -- Clinical features of Cushing's syndrome -- Laboratorial diagnosis of Cushing's syndrome: differential diagnosis with pseudo Cushing's conditions as obesity, alcoholism and depression -- Laboratorial diagnosis of Cushing's syndrome: differential diagnosis among the different causes of ACTH-dependent and ACTH-independent Cushing's syndrome -- Imaging for the differential diagnosis of Cushing's syndrome: MRI, CT, and isotopic scanning -- Inferior petrosal sampling for the differential diagnosis of ACTH-dependent Cushing's syndrome -- The surgical management of Cushing's disease -- Adrenal-directed treatment options for Cushing's disease -- Radiation therapy and stereotactic radiosurgery for Cushing's disease -- Medical management of Cushing's syndrome -- ACTH-dependent Cushing syndrome: clinical and diagnostic aspects, and treatment approaches for ectopic Cushing's syndrome -- Revisiting the Nelson's syndrome: corticotroph tumor progression after bilateral adrenalectomy in Cushing's disease -- ACTH-independent Cushing's syndrome: adrenocortical tumors -- ACTH-independent Cushing's syndrome: bilateral macronodular hyperplasia -- ACTH-independent Cushing's syndrome: primary pigmented nodular adrenal disease in the context of Carney's complex -- Glucocorticoid resistance -- Post-operative replacement and assessment of HPA axis recovery in Cushing's syndrome -- Special aspects of Cushing's syndrome: pregnancy -- Special aspects of Cushing's syndrome: childhood -- Special aspects of Cushing's syndrome: cyclic Cushing's syndrome.
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Cushing's syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. "Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment" reviews the difficulties in distinguishing Cushing's syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establi.