Front Cover; Advances in Cancer Research, Volume 60; Copyright Page; Contents; Contributors; Chapter 1. Structural and Functional Diversity in the FGF Receptor Multigene Family; I. Introduction; II. The FGF Family of Polypeptide Mitogens; III. Early Binding and Cross-Linking Studies of the FGF Receptor; IV. Nomenclature of the FGF Receptor Genes; V. Purification, cDNA Cloning, and Characterization of FGFR 1; VI. Characterization of EFGR 2, FGFR 3, and FGFR 4; VII. Multiple Forms of FGFR 1 and FGFR 2 Are Generated by Alternative Splicing; VIII. Multiple Forms of FGFR 1
I. The Multidrug Transporter as a Cause of Multidrug ResistanceII. Regulation of Expression of mdr Genes; III. Summary and Conclusions; Reference; Chapter 6. Relationship between MYC Oncogene Activation and MHC Class I Expression; I. Introduction; II. MHC Class I Expression and Cancer; III. Modulation of MHC Class I Expression by Oncogences; IV. Molecular Mechanism of MHC Class I Regulation by Oncogenes; V. Biological Consequences of MHC Class I Downmodulation by Oncogenes; VI. Concluding Remarks; References; Chapter 7. Immunosuppressive Factors in Human Cancer; I. Introduction
IX. Multiple Forms of FGFR 2X. FGFR 3 and FGFR 4; XI. Ligand Binding Specificities of the Cloned FGF Receptors; XII. Alternative Splicing in the Third Ig Domain Is Important for Determining Ligand Binding Specificities; XIII. Analogous Splice Variants from Different FGF Receptor Genes Encode Receptor Forms with Different Ligand Binding Specificities; XIV. Regulation of FGF Receptor Expression; XV. Cell- and Tissue-Specific Alternative Splicing of FGF Receptor mRNAs; XVI. Differential, Tissue-Specific Expression of the Different ' FGF Receptor Genes; XVII. The Drosophila FGF Receptor
V. Chromosomal AbnormalitiesVI. Tumor Suppressor Genes; VII. Gene Amplification; VIII. Predictors of Tumor Behavior; IX. Molecular Cloning of Translocation Breakpoints; X. Future Developments; Reference; Note Added in Proof; Chapter 4. Genomic instability and Tumor Progression: Mechanistic Considerations; I. Introduction; II. Genomic Stability and Instability: Background and Implications; III. Mechanisms of Genomic Stability and Instability; IV. Quantitative Considerations; V. Summary and Perspectives; References; Chapter 5. Function and Regulation of the Human Multidrug Resistance Gene
XVIII. FGF Receptor-Mediated Signal TransductionXIX. Concluding Remarks; References; Chapter 2. Protein Tyrosine Kinase Growth Factor Receptors and Their Ligands in Development, Differentiation, and Cancer; I. Introduction; II. Structure of Receptor Protein Tyrosine Kinases; III. RTKs in Development; IV. RTKs and Tumorigenesis; V. Genetics and Cancer; Reference; Chapter 3. The Molecular and Genetic Characterization of Human Soft Tissue Tumors; I. Introduction; II. Tumor Etiology; III. Genetic Susceptibility to Soft Tissue Tumors; IV. Detection of ras Gene Activation