Front Cover; Advances in Cancer Research, Volume 37; Copyright Page; Contents; Contributors to Volume 37; Chapter 1. Retroviruses and Cancer Genes; I. Introduction; II. Introducing Retrovirus Oncogenes; III. Properties of Retrovirus Oncogenes and Their Products; IV. The Origin of Retrovirus Oncogenes: Emergence of the Thesis; V. The Discovery of c-oncs; VI. Characterizing c-oncs; VII. C-oncs Are Cellular Genes; VIII. The Expression of c-oncs; IX. Proteins Encoded by C-oncs; X. How Similar Are Viral Oncogenes and c-oncs?; XI. Are c-oncs Members of a Multigene Family?
Chapter 4. Pericellular Matrix in Malignant TransformationI. Introduction; II. Components of the Extracellular Matrix and Their Functions; III. Pericellular Matrix and the Cellular Phenotype in Vitro; IV. Malignant Transformation: Altered Biosynthesis of Matrix Components and Failure to Deposit Them; V. Tumorigenicity Invasion and Metastasis; VI. Proteins of Basement Membranes and Interstitial Matrix as Characteristics of Tumor Cells; VII. Cell-Matrix Interaction and Anchorage Dependence of Normal Cells
IV. Description of the Drosophila Tumor MutantsV. Viruses Found in Drosophila Tumor Cells; VI. Retroviral Oncogenes and Their Cellular Counterparts in Different Animal Species; VII. Transfection and Vertebrate Tumor Genes: A Comparison with Drosophila; VIII. Concluding Remarks; References; Chapter 3. Transformation-Associated Tumor Antigens; I. Introduction; II. Simian Virus 40; III. Adenoviruses; IV. Epstein-Barr Virus; V. Methylcholanthrene-Induced Transformed Cells (Meth A); VI. Abelson Virus; VII. Rous Sarcoma Virus; VIII. Teratocarcinomas; IX. Conclusions; References
VIII. Molecular Mechanisms of Altered Cell-Matrix Interaction in Rous Sarcoma Virus TransformationReferences; Chapter 5. Radiation Oncogenesis in Cell Culture; I. Foreword; II. Introduction; III. Cell Transformation in Vitro; IV. Radiation Oncogenesis in Vitro; V. Discussion; References; Chapter 6. Mhc Restriction and Ir Genes; I. Mhc through a Keyhole; II. How Was Mhc Restriction Discovered?; III. Mhc Restriction of Cytolytic Responses; IV. Mhc Restriction of Regulatory Responses; V. Mhc Restriction of DTH and CS Responses; VI. The Puzzle of the Class I and Class II Gene Dichotomy
XII. How Might Retroviruses Transduce Cellular Genes?XIII. What Is the Function of c-oncs in Normal Cells?; XIV. The Paradox of Neoplastic Transformation by Retrovirus Oncogenes; XV. Does the Homology between Viral Oncogenes and c-oncs Dictate the Host Range of Viral Transformation?; XVI. Do c-oncs Provide a Pathway for Oncogenesis?; XVII. Conclusion: The Pursuit of Cancer Genes; References; Chapter 2. Cancer, Genes, and Development: The Drosophila Case; I. Introduction; II. Drosophila Development; III. General Information on the Drosophila Tumor Mutants