Front cover; Preface; Contents; Chapter 1. Introduction; Chapter 2. Background for Nonchemists; Chapter 3. Background for Chemists; Chapter 4. Oxidation Pathways and the Enzymes That Mediate Them; Chapter 5. Reductive Pathways; Chapter 6. Hydrolytic Pathways; Chapter 7. Conjugation Pathways; Chapter 8. Reactive Metabolites; Practice Problems; Answers to Practice Problems; Index; Back cover.
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In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students through the recognition of the chemical underpinnings of drug metabolism. While there are numerous resources available for understanding drug structure, and other texts relating to drug metabolism from a biological standpoint, there is no other resource c.