عنوان

Gene therapy in reconstructive and regenerative surgery /

3319789570

3319789589

9783319789576

9783319789583

3319789562

9783319789569

Gene therapy in reconstructive and regenerative surgery /

[Book]

Giorgio Giatsidis, editor.

Cham, Switzerland :

Springer,

2018.

1 online resource

Principles of gene therapy in reconstructive and regenerative surgery -- Gene therapy in skin and wound healing -- Gene therapy in pathologic scars -- Gene therapy in skeletal muscle repair and regeneration -- Gene therapy in cartilage repair and regeneration -- Gene therapy in tendon repair and regeneration -- Gene therapy and free flaps for therapeutic reconstructive surgery-- Developing a gene therapy clinical trial : tips and tricks -- Future directions in reconstructive and regenerative surgery.

0

This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.

Springer Nature

com.springer.onix.9783319789576

Gene therapy in reconstructive and regenerative surgery.

9783319789569

Gene therapy.

Regenerative medicine.

Genetic Therapy.

Cellular biology (cytology)

Gene therapy.

MEDICAL-- Pharmacology.

Plastic & reconstructive surgery.

Regenerative medicine.

MED-- 071000

MNP

MNP

Giatsidis, Giorgio

20200823113959.0

pn

[Book]

Y