عنوان

Polymeric gene delivery systems /

3319778668

3319778676

9783319778662

9783319778679

331977865X

9783319778655

Polymeric gene delivery systems /

[Book]

Yiyun Cheng, editor ; with contributions from Narsireddy Amreddy [and more].

Cham, Switzerland :

Springer,

[2018]

1 online resource

Topics in current chemistry collections,

2367-4067

Intro; Contents; Preface; History of Polymeric Gene Delivery Systems; Abstract; 1 Introduction; 2 First-Generation Polycations: DNA Binding, Compaction, and Targeting; 3 Second-Generation Polycations: Proton Sponges or Endosomolytic Polymers; 4 Third-Generation Polycations: Biodegradable and Biocompatible; 5 Pharmaceutical Precise Polymers; 6 Polymer-Containing Nanocomposites; 7 Virus-Inspired Multifunctional Dynamic Polymers; 8 Conclusions and Perspectives; Acknowledgements; References; Polymer -- Nucleic Acid Interactions; Abstract; 1 Introduction; 2 Structure of DNA and siRNA; 2.1 DNA; 2.2 siRNA3 Theories of DNA Interacting with Polymers; 3.1 Electrostatic Interaction; 3.2 Hydrophobic Interaction; 3.3 Hydrogen Bonds; 4 DNA/siRNA -- Linear Polymer Interactions; 4.1 DNA/siRNA Condensation via Electrostatic Interaction; 4.2 Optimization of Polymers by Hydrophobic Interactions; 4.3 Polyplex Dissociation; 5 DNA/siRNA -- Dendrimer/Dendron Interactions; 5.1 Electrostatic Interaction with Different Dendrimer Sizes; 5.2 Hydrogen Bonds by Surface Modification; 5.3 Hydrophobic Modulation by Surface Modification; 5.4 Flexibility of Dendrimers; 6 Conclusion and perspectives; Acknowledgements; References; Polysaccharide-based Nanoparticles for Gene Delivery; Abstract; 1 Introduction; 1.1 Chitosan; 1.2 Alginate; 1.3 Dextran; 1.4 Hyaluronan; 1.5 Pullulan; 1.6 Other Polysaccharides; 2 DNA Delivery; 3 siRNA Delivery; 4 Conclusion; Acknowledgements; References; Peptide-Based and Polypeptide-Based Gene Delivery Systems; Abstract; 1 Introduction; 2 Preparation of Peptide-Based and Polypeptide-Based Gene Carriers; 2.1 Directly Obtained from the Organism; 2.2 Obtained by Genetic Engineering; 2.3 Artificial Peptides; 3 Primary Types of Peptide-Based and Polypeptide-Based Delivery Systems; 3.1 Polypeptide Directly Conjugated to Genetic Material; 3.2 Peptide-Based or Polypeptide-Based Gene Carriers; 4 Application of Functional Peptides in Gene Therapy; 4.1 Targeted Peptides for Pathological Tissues or Cells; 4.2 Cell-Penetrating Peptides; 4.3 Peptides with Endosomal Escape Capacity; 4.4 Nuclear Localization Signal Peptides; 4.5 Peptide-Based Hydrogel for Local Release of Genes; 4.6 Environmentally Responsive Peptides; 4.7 Multifunctional Peptide-Based Gene Delivery Systems; 5 Conclusion and Outlook; Acknowlegements; References; Degradable Polyethylenimine-Based Gene Carriers for Cancer Therapy; Abstract; 1 Introduction; 2 Degradable PEI Derivatives; 2.1 Ester Bond; 2.2 Disulfide Bond; 2.3 Imine Bond; 2.4 Carbamate Bond; 2.5 Amide Bond; 2.6 Ketal Bond; 2.7 Others; 3 Major Cancers: Application of Degradable PEI-Based Gene Carriers; 3.1 Lung Cancer; 3.2 Prostate Cancer; 3.3 Liver Cancer; 3.4 Breast Cancer; 3.5 Ovarian Cancer; 3.6 Cervical Cancer; 3.7 Melanoma; 3.8 Colon Cancer; 3.9 Other Cancers (Lymphoma, Glioblastoma, and Neuroma); 4 Conclusion and Future Perspectives; Acknowledgements

0

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

9783319778655

Gene therapy.

Polymeric drug delivery systems.

Drug Delivery Systems.

Polymers.

Gene therapy.

MEDICAL-- Pharmacology.

Polymeric drug delivery systems.

MED-- 071000

PNNP

PNNP

Cheng, Yiyun.

20200823112641.0

pn

[Book]

Y