عنوان
پدید آورنده
موضوع
رده
RB155 .M53 2019
RB155
.
M53
2019
کتابخانه
محل استقرار
1788016424
1788017811
9781788016421
9781788017817
1788013948
9781788013949
MicroRNAs in diseases and disorders :
[Book]
emerging therapeutic targets /
edited by Philip V. Peplow, Bridget Martinez, George A. Calin and Aurora Esquela-Kercher.
Croydon, UK :
Royal Society of Chemistry,
[2019]
©2019
1 online resource (xx, 480 pages) :
illustrations
Drug discovery series ;
69
Includes bibliographical references and index.
Intro; HalfTitle; series Editor; Title; Preface; Dedication; Copyright; Contents; Chapter 1 Role of Nutrition, the Epigenome, and MicroRNAs in Cancer Pathogenesis 1; 1.1 Introduction; 1.2 Epigenetic Link to Cancer; 1.3 miRNAs are Closely Associated with Human Cancer; 1.3.1 miRNA Biogenesis is Complex; 1.3.2 miRNAs as Tumor Suppressors and Oncogenic Factors; 1.3.3 Extracellular Delivery of miRNAs; 1.4 miRNAs and the Epigenome; 1.4.1 miRNAs that Regulate the Epigenetic Machinery; 1.4.2 miRNAs Targeted by the Epigenetic Machinery; 1.5 miRNAs, Dietary Factors, and the Epigenome; 1.5.1 Resveratrol
1.5.2 Ellagitannins and Ellagic Acid1.5.3 Epigallocatechin-3-gallate; 1.5.4 Genistein; 1.5.5 Curcumin; 1.5.6 Diindolylmethane; 1.6 miRNAs, the Microbiota, and Colon Cancer; 1.6.1 Microbial-produced Butyrate Influences Host miRNA Expression; 1.6.2 Butyrate Acts as a Histone Deacetylase Inhibitor in Cancer Cells; 1.6.3 Anti-tumor Effects of Butyrate and miRNA Expression in the Colon; 1.6.4 Butyrate's Role in Liver Cancer, the Epigenome, and miRNAs; 1.7 Plant-derived XenomiRs Impact Cancer Pathways in Human Cells; 1.7.1 Ingested Plant miRNAs Regulate Recipient Cell Targets
1.7.2 Plant miRNAs Impact Cancer Gene Expression1.8 Conclusion; Acknowledgements; References; Chapter 2 Role of MicroRNAs in Metabolic Diseases 36; 2.1 Introduction; 2.1.1 The Innate Immune System in Obesity-mediated Insulin Resistance and T2DM; 2.1.2 miRNAs and the Etiology of T2DM; 2.2 miR-122 is Elevated in Obesity and Human Metabolic Disease; 2.3 miR-126 is Downregulated in T2DM and Human Metabolic Disease; 2.4 miR-146a is Downregulated in Human Obesity and Diabetic Kidney Disease; 2.5 miR-155 is Downregulated in Human Obesity and NAFLD
2.6 miR-21 is Differentially Expressed in Obesity, T2DM, and Human Metabolic Syndrome2.7 miR-223 is Important in T2DM, Although Reports Conflict on Direction of Differential Expression; 2.8 miR-27a is Elevated in T2DM; 2.9 miR-29a is Elevated in T2DM; 2.10 miR-34a is Elevated in Obesity and T2DM; 2.11 miR-375 is Elevated in T2DM; 2.12 miRNAs as Biomarkers in Metabolic Disease; Acknowledgements; References; Chapter 3 Circulating MicroRNAs as Biomarkers of Celiac Disease and Other Intestinal Pediatric Diseases: Experimental and Bioinformatics Challenges From Bench to Bedside 76
3.1 Introduction3.1.1 Biogenesis and Regulatory Functions of miRNAs; 3.1.2 Biogenesis, Stability and Cellular Recognition of Circulating miRNAs; 3.1.3 Circulating miRNAs and Toll-like Receptors; 3.1.4 The Role of miRNAs in Intestinal Development and Homeostasis; 3.2 Celiac Disease; 3.3 Intestinal miRNAs of Celiac Disease Patients; 3.4 Circulating miRNAs of Celiac Disease Patients; 3.5 Regulation of Post-transcriptional Gene Expression by miRNAs in Celiac Disease; 3.6 Circulating miRNAs in Inflammatory Bowel Disease; 3.7 Experimental and Bioinformatics Challenges for miRNA Analysis
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MicroRNAs in Diseases and Disorders highlights the role of miRNAs in the development and progression of a variety of diseases and the utilization of miRNA targets in treatment. This book also includes the use of miRNAs as diagnostic and prognostic biomarkers for disease.
Royal Society of Chemistry
5429:5278
9781788013949
Medical genetics.
MicroRNA.
HEALTH & FITNESS-- Diseases-- General.
MEDICAL-- Clinical Medicine.
MEDICAL-- Diseases.
MEDICAL-- Evidence-Based Medicine.
Medical genetics.
MEDICAL-- Internal Medicine.
MicroRNA.
HEA-- 039000
MED-- 014000
MED-- 022000
MED-- 045000
MED-- 112000
616
.
042
23
RB155
.
M53
2019
Calin, George A., (George Adrian)
Esquela-Kerscher, Aurora
Martinez, Bridget
Peplow, Philip, (Philip V.)
20200823055947.0
pn
مطالعه متن کتاب [Book]
Y
