عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
TL48663
انگلیسی
Expanding the genetic code for synthesis of proteins with native biological modifications and novel chemical, biophysical probes
[Thesis]
Yan-Jiun Lee
Liu, Wenshe R.
Texas A&M University
2015
190
Committee members: Begley, Tadhg P.; Pellois, Jean-Philippe; Watanabe, Coran M. H.
Place of publication: United States, Ann Arbor; ISBN=978-1-339-52456-6
Ph.D.
Chemistry
Texas A&M University
2015
Engineering of protein with new modifications essentially expands the protein functions which provide powerful tools for investigating significant biological questions. New modifications also offer scientists the ability to handle protein activity at will. Therefore, development of facile and robust protein modification protocol is highly desirable in almost every aspect of biological research. In combination with chemistry and biology principles, the genetic code expansion technology has emerged as an effective strategy for manipulating proteins and interrogating biological systems. In this regard, the overall objective of the presented research is to expand the chemical biology toolbox based on noncanonical amino acid incorporation and bioorthogonal chemistry.
Biochemistry
Pure sciences;Bioconjugation;Bioorthogonal reaction;Genetic code expansion;Noncanonical amino acid
Ouji, Leila Anna
Liu, Wenshe R.
Chemistry
Texas A&M University
1771301552; 10026470
مطالعه متن کتاب p
[Thesis]
276903
a
Y
