The Proteasome - Ubiquitin Protein Degradation Pathway
[Book]
edited by Peter Zwickl, Wolfgang Baumeister.
Berlin, Heidelberg
Springer Berlin Heidelberg
2002
(x, 208 pages 17 illustrations)
Current topics in microbiology and immunology, 268.
Molecular Evolution of Proteasomes --; The 20S Proteasome --; Regulation the 26S Proteasome --; The 11S Regulators of 20S Proteasome Activity --; Immunological Functions of the Proteasome --; Natural Substrates of the Proteasome and their Recognition by the Ubiquitin System --; The Intracellular Localization of the Proteasome --; Proteasome Inhibitors: Complex Tools for a Complex Enzyme --; Subject Index.
This volume gives a complete overview of the structure and function of the proteasome, its regulators and inhibitors, and its cellular importance, in conjunction with the ubiquitin system, for the degradation of regulatory proteins and the generation of immunogenic peptides. The topics range from the molecular evolution of the proteasome and its associated activators, the proteasome in the immune response, to proteasome inhibitors.