عنوان

Subcellular Basis of Contractile Failure Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Soci.

1461315131

9781461315131

b560360

Subcellular Basis of Contractile Failure Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Soci.

[Book]

Korecky, Borivoj; Dhalla, Naranjan S.

Springer Verlag

2011

I. Role of Cations in Heart Function.- 1. Role for sodium channels and intracellular sodium in regulation of the cardiac force-frequency relation and contractility.- 2. Regulation of cardiac calcium current during suppression of second messenger intracellular enzymatic pathways.- 3. Hormonal and non-hormonal regulation of Ca2+ current and adenylate cyclase in cardiac cells.- 4. Calcium current in normal and hypertrophied isolated rat ventricular myocytes.- 5. Regulation of contractile activity in single adult cardiomyocytes isolated from four different species: The effect of reduced sodium gradient.- 6. Involvement of sodium-calcium exchange in cardiac pathology.- 7. Modifications in sarcolemmal regulation of Ca2+ with aging.- II. Cardiac Hypertrophy and Cardiomyopathies.- 8. Alterations of membrane proteins in cardiac hypertrophy.- 9. Signal transduction in myocardial hypertrophy and myosin expression.- 10. Molecular and subcellular mechanisms of thyroid hormone induced cardiac alterations.- 11. Membrane abnormalities and changes in cardiac cations due to alterations in thyroid status.- 12. Inhibitory effects of captopril on the onset of cardiomyopathy in cardiomyopathic hamsters.- 13. Altered myocardial contractility and energetics in renovascular hypertensive rats.- 14. Cardiac phosphatidylethanolamine N-methylation in normal and diabetic rats treated with L-propionylcarnitine.- III. Ischemic Heart Disease and Cardiac Failure.- 15. Dietary N-3 polyunsaturated fatty acids and ischemic heart disease.- 16. Role of free radicals in the development of ischemic heart disease.- 17. Cardiovascular membranes as models for the study of free radical injury.- 18. Oxidation of myofibrillar thiols: A mechanism of contractile dysfunction reversible by dithiothreitol.- 19. Cardiac contractile failure due to oxygen radicals in an ex vivo system.- 20. Subcellular basis of contractile failure in myocytes: Calcium overload or energy depletion?.

Korecky, Borivoj; Dhalla, Naranjan S.

Korecky, Borivoj; Dhalla, Naranjan S.

[Book]

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