1 Prokaryotic Control of Transcription: How and Why Does It Differ From Eukaryotic Control? --;2 The Heat Shock Transcriptional Response --;3 The Role and Regulation of the Jun Proteins in Response to Phorbol Ester and UV Light --;4 NF-?B: A Mediator of Pathogen and Stress Responses --;5 PPAR: A Key Nuclear Factor in Nutrient/Gene Interactions? --;6 Mechanism of Signal Transduction by the Basic Helix-Loop-Helix Dioxin Receptor --;7 Transcriptional Regulation by Heavy Metals, Exemplified at the Metallothionein Genes --;8 Post-Transcriptional Regulation of Gene Expression by Iron.
The key elements controlling transcription initiation in eukaryotes are activator proteins (transactivators) that bind in a sequence-specific manner to short DNA sequences in the of genes. The do novo binding of an activator to DNA or, if already bound to DNA, its functional activation is what ultimately turns on a high-level expression of genes.