عنوان

Reproduction DNA Animal Viruses.

1468427032

9781468427035

b554954

Reproduction DNA Animal Viruses.

[Book]

Fraenkel-conrat, H.

Springer Verlag

2013

1 Parvovirus Reproduction.- 1. Introduction.- 1.1. Definitions.- 1.2. Classification.- 2. Biological Properties.- 2.1. Stability.- 2.2. Host Range and Pathogenicity.- 2.3. Persistent Infection and Latency.- 2.4. Defectiveness.- 2.5. Interference.- 3. Properties and Components of Virions.- 3.1. Physicochemical Properties of Virions.- 3.2. DNA.- 3.3. Protein.- 4. Multiplication of Nondefective Parvoviruses.- 4.1. Infectious Cycle.- 4.2. Viral DNA Synthesis.- 4.3. Viral Protein Synthesis.- 4.4. Cellular Requirement.- 4.5. Cellular Impairment.- 5. Multiplication of Defective Parvoviruses.- 5.1. Infectious Cycle.- 5.2. Helper Requirement.- 5.3. Viral RNA.- 6. Conclusions.- 7. References.- 2 Reproduction of Papovaviruses.- 1. General Properties of Papovaviruses.- 1.1. Initiation of the Replication Cycle-Adsorption, Penetration, and Uncoating of the Virus.- 1.2. Time Course of Synthesis of Viral Macromolecules.- 2. DNA Replication.- 2.1. DNA Configurations.- 2.2. Structure of Replicating Molecules.- 2.3. Cleavage of SV40 DNA by Bacterial Restriction Endonucleases.- 2.4. Site of Initiation and Direction of DNA Replication.- 2.5. Mechanism of Chain Growth.- 2.6. Termination of DNA Synthesis.- 2.7. Mechanism for Effecting Semiconservative Replication of Covalently Closed Duplex DNA.- 2.8. SV40 DNA Synthesis in Heterokaryons of SV40-Transformed Cells and Cells Permissive for SV40.- 2.9. SV40 DNA-Containing Cellular DNA Sequences.- 2.10. The Role of Proteins in DNA Replication.- 3. Transcription of SV40 and Polyoma DNA.- 3.1. Strand Orientation of Transcription.- 3.2. Control of Late Transcription.- 3.3. Size of the Papovavirus-Specific RNA.- 3.4. Cytoplasmic Viral RNA.- 3.5. Concentration of Virus-Specific RNA.- 3.6. Selection of Viral mRNA.- 3.7. Mapping of Transcriptional Sites on the SV40 Genome.- 3.8. The Direction of SV40 DNA Transcription.- 3.9. In Vitro Studies of Transcription.- 3.10. The Applications of In Vitro Virus-Specific RNA.- 3.11. TranscriSption of SV40 DNA by Mammalian Polymerases.- 4. The Proteins of SV40 and Polyoma.- 4.1. Early Antigens.- 4.2. Induction of Host Cell Proteins.- 4.3. Virion-Associated Endonucleases.- 4.4. Structural Proteins of SV40 and Polyoma.- 4.5. Internal Proteins.- 4.6. The SV40 Helper Function for Adenovirus Replication in Monkey Cells.- 5. Other Properties of Papovaviruses.- 5.1. Induction of Cellular Processes in Infected Cells.- 5.2. Pseudovirions.- 5.3. Nucleoprotein Complexes.- 5.4. Adenovirus-SV40 Hybrid Viruses.- 6. References.- 3 Reproduction of Adenoviruses.- 1. Introduction.- 2. Architecture and Composition of the Virion.- 3. Biochemistry of the Structural Proteins of Adenovirus.- 4. The Adenovirus Genome.- 5. Classification of Adenoviruses.- 6. The Productive Infection.- 6.1. Early Interaction between Virus and Cell.- 6.2. Early Transcription.- 6.3. Late Transcription.- 6.4. A Comparison between Cellular and Viral Mrna Production.- 6.5. Adenovirus DNA Replication.- 6.6. Translation.- 6.7. Host Cell Macromolecular Synthesis.- 6.8. Control Mechanisms.- 6.9. Assembly of Adenoviruses.- 7. Abortive Infections.- 7.1. Abortive DNA Replication.- 7.2. Abortive Translation.- 7.3. Adeno-SV40 Hybrid Viruses.- 8. Cell Transformation.- 8.1. Cell Transformation by Different Adenoviruses.- 8.2. Viral DNA in Transformed Cells.- 8.3. Transcription.- 8.4. Phenotype of the Transformed Cells.- 9. Adenovirus Genetics.- 10. Conclusions and Prospects for the Future.- 11. References.- 4 The Replication of Herpesviruses.- 1. Objectives and Scope.- 1.1. Objectives.- 1.2. The Herpesviruses.- 2. The Herpesvirion.- 2.1. Architectural Components.- 2.2. Purification and Fractionation of Herpesviruses.- 2.3. Herpesvirus DNA.- 2.4. Herpesvirus Proteins.- 2.5. Polyamines.- 2.6. Lipids.- 2.7. Topology of Structural Components in the Herpesvirion.- 2.8. Variability of Virion Proteins among Wild and Laboratory Strains.- 2.9. The Function of Structural Components in Relation to Particle Infectivity.- 3. Biosynthesis of the Virus in Permissive Cells.- 3.1. The Reproductive Cycle and Its Outcome.- 3.2. Entry of the Virus into the Cell.- 3.3. Viral RNA Synthesis and Metabolism.- 3.4. Viral Protein Synthesis and Metabolism.- 3.5. Enzymes Specified by Herpesviruses.- 3.6. Herpesvirus DNA Synthesis.- 3.7. Biosynthesis of Other Constituents of the Virion.- 3.8. The Morphogenesis and Egress of the Virion from Infected Cells.- 4. Alterations of Cellular Function and Structure During Productive Infection.- 4.1. General Considerations.- 4.2. Alterations in Host Macromolecular Metabolism.- 4.3. Alteration in the Structure and Function of Cellular Membranes.- 4.4. The Structural Changes.- 4.5. Conclusions.- 5. References.- 5 Reproduction of Poxviruses.- 1. Introduction.- 2. Subgroups.- 3. Virions.- 3.1. Morphology.- 3.2. Physical Properties.- 3.3. Chemical Composition.- 3.4. Size and Structure of DNA.- 3.5. Proteins.- 4. Growth Cycle.- 4.1. Single-Step Infection.- 4.2. Adsorbtion, Penetration, and Uncoating.- 4.3. Transcription.- 4.4. DNA Replication.- 4.5. Regulation of Protein Synthesis.- 4.6. Post-Translational Modification.- 4.7. Morphogenesis.- 4.8. Dissemination of Virus and Modification of Host Membranes.- 5. Effects on Host Cell Metabolism.- 5.1. Cytopathic Effects.- 5.2. Macromolecular Synthesis.- 5.3. Cell Proliferation.- 6. Interference with Poxvirus Replication.- 6.1. Antiviral Substances.- 6.2. Dual Viral Infections.- 7. Summary.- 8. References.- Addendum to Chapter 2.

Fraenkel-conrat, H.

Fraenkel-conrat, H.

[Book]

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