Animal Models of Folate-Related Neural Tube Defects Nicholas D. E. Greene and Andrew J. Copp Genetic Variation in Folate Metabolism: Impact on Development Rima Rozen Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic Nondisjunction and Down Syndrome S. Jill James and Charlotte A. Hobbs Folic Acid, Vitamin B12, and Genomic Stability of Human Cells Michael Fenech Molecular Genetics of Folate Metabolism Manuela Foedinger, Sonja Skoupy, and Gere Sunder-Plassmann Folate Receptor-a: An Update Barton A. Kamen Folate, Homocysteine, and Neural Tube Defects Tom K. A. B. Eskes Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects Robert C. Barber, Janee van Waes, Edward J. Lammer, Gary M. Shaw, Thomas H. Rosenquist, and Richard H. Finnell Developmental Toxicants Potentially Acting via Folate Perturbation Deborah K. Hansen Brain Development and Choline, the Other Methyl Donor Steven H. Zeisel Nutrient Interactions Between Folate and Zinc or Copper: Their Possible Implications to Pregnancy Outcome Tsunenobu Tamura Regulation of Folate Metabolism by Iron A. Katherine Herbig and Patrick J. Stover A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions: The Importance of Folate Status and Genotype Mark Lucock and Zoe Yates Vascular Disease in Women: Folate and Homocysteine Tom K. A. B. Eskes Folate, Homocysteine, and Cardiovascular Disease Jayne V. Woodside and Ian S. Young