Resistance to targeted therapies as a result of mutation(s) in the target / Alexis B. Cortot and Pasi A. Jänne -- The dynamics of the cell signaling network; implications for targeted therapies / Daniel Gioeli -- Cancer signaling network analysis by quantitative mass spectrometry / Jason R. Neil and Forest M. White -- Development and implementation of array technologies for proteomics : clinical implications and applications / Julie D. Wulfkuhle ... [et. al] -- Using phosphoflow[tm] to study signaling events of subpopulations resistant to current therapies / Omar D. Perez -- Mathematical and computational models in cancer / Sudhir Chowbina ... [et al.] -- Somatic evolution of acquired drug resistance in cancer / John W. Pepper -- Interrogating resistance to targeted therapy using genetically engineered mouse models of cancer / Edward Gunther -- microRNA : a potential therapy able to target multiple cancer pathways / Benjamin Kefas and Benjamin W. Purow -- Rational combination of targeted agents to overcome cancer cell resistance / Yun Dai and Steven Grant.