عنوان

Recent advances in retinal degeneration /

0387740406

0387749020

9780387740409

9780387749020

dltt

Recent advances in retinal degeneration /

[Book]

Robert E. Anderson, Matthew M. LaVail and Joe G. Hollyfield, editors.

New York, N.Y. :

Springer,

©2008.

xxxiv, 423 pages :

illustrations, portrait.

Advances in experimental medicine and biology ;

v. 613

"XII International Symposium on Retinal Degeneration (also known as RD2006) held October 23-28, 2006 in San Carlos de Bariloche, Argentina"--Preface.

Includes bibliographical references and index.

Part I: Keynote lectures -- Curing blindness with stem cells: hope, reality, and challenges / Ruben Adler -- Retinal degenerations: planning for the future / Eliot L. Berson -- Part II: Neuroprotection -- Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1 / Nicolas G. Bazan -- On the role of CNTF as a potential therapy for retinal degeneration: Dr. Jekyll or Mr. Hyde? / William A. Beltran -- Nanoceria particles prevent ROI-induced blindness / Junping Chen [and others] -- An in-vivo assay to identify compounds protective against light induced apoptosis / Yogita Kanan [and others] -- Role of BCL-XL in photoreceptor survival / Yun-Zheng Le [and others] -- The hypoxic transcriptome of the retina: identification of factors with potential neuroprotective activity / Markus Thiersch [and others] -- Part III: Gene therapy and neuroprotection -- Lentiviral gene transfer-mediated cone vision restoration in RPE65 knockout mice / Alexis-Pierre Bemelmans [and others] -- In vitro analysis of ribozyme-mediated knockdown of an ADRP associated rhodopsin mutation / Dibyendu Chakraborty [and others] -- Gene therapy for mouse models of ADRP / Marina S. Gorbatyuk, William W. Hauswirth, and Alfred S. Lewin -- Development of viral vectors with optimal transgene expression for ocular gene therapies / Takao Hashimoto -- Adeno-associated viral vectors and the retina / John J. Alexander and William W. Hauswirth -- Genetic supplementation of RDS alleviates a loss-of-function phenotype in C214S model of retinitis pigmentosa / May Nour, Steven J. Fliesler, and Muna I. Naash -- Morphological aspects related to long-term functional improvement of the retina in the 4 years following rAAV-mediated gene transfer in the RPE65 null mutation dog / Kristina Narfström [and others] -- Virus-mediated gene delivery to neuronal progenitors / Tonia S. Rex -- Part IV: Animal models of retinal degeneration -- Loss of visual and retinal function in light-stressed mice / Drew Everhart [and others] -- ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration / Goldis Malek [and others] -- Oxygen supply and retinal function: insights from a transgenic animal model / Edda Fahl [and others] -- Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray / Gerardo L. Paez [and others] -- Toward a higher fidelity model of AMD / Brian J. Raisler [and others] -- The potential of ambient light restriction to restore function to the degenerating P23H-3 rat retina / Krisztina Valter, Diana K. Kirk, and Jonathan Stone -- Part V: Molecular genetics and candidate genes -- Mutations in known genes account for 58% of autosomal dominant retinitis pigmentosa (adRP) / Stephen P. Daiger [and others] -- Genetics of age-related macular degeneration / Albert O. Edwards -- Retinal phenotype of an X-linked pseudo-usher syndrome in association with the G173R mutation in the RPGR gene / Alessandro Iannaccone [and others] -- Mutation in the PYK2-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5) in two swedish families / Linda Koḧn [and others] -- Identification and characterization of genes expressed in cone photoreceptors / Mehrnoosh Saghizadeh, Novrouz B. Akhmedov, and Debora B. Farber -- Clinical and genetic characterization of a chinese family with CSNB1 / Ruifang Sui [and others] -- 10q26 is associated with increased risk of age-related macular degeneration in the Utah population / D. Joshua Cameron [and others] -- Part VI: Diagnostic, clinical, cytopathological and physiologic aspects of retinal degeneration -- Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization / Kutralanathan Renganathan [and others] -- A possible impaired signaling mechanism in human retinal pigment epithelial cells from patients with macular degeneration / Piyush C. Kothary and Monte A. Del Monte -- Expression and cell compartmentalization of EFEMP1, a protein associated with malattia leventinese / Adam Kundzewicz, Francis Munier, and Jean-Marc Matter -- Role of ELOVL4 in fatty acid metabolism / Vidyullatha Vasireddy [and others] -- Organization and molecular interactions of retinoschisin in photoreceptors / Camasamudram Vijayasarathy [and others] -- Part VII: Basic science underlying retinal degeneration -- Proteomics profiling of the cone photoreceptor cell line, 661W / Muayyad R. Al-Ubaidi [and others] -- y-secretase regulates VEGFR-1 signalling in vascular endothelium and RPE / Michael E. Boulton [and others] -- Analysis of the rate of disk membrane digestion by cultured RPE cells / Tanja Diemer, Daniel Gibbs, and David S. Williams -- Functional expression of cone cyclic nucleotide-gated channel in cone photoreceptor-derived 661W cells / J. Browning Fitzgerald [and others] -- Phosphorylation of caveolin-1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase / Michael H. Elliott and Abboud J. Ghalayini -- Regulation of neurotrophin expression and activity in the retina / Abigail S. Hackam -- Involvement of guanylate cyclases in transport of photoreceptor peripheral membrane proteins / Sukanya Karan, Jeanne M. Frederick and Wolfgang Baehr -- Rod progenitor cells in the mature zebrafish retina / Ann C. Morris, Tamera Scholz, and James M. Fadool -- αγβ5 integrin receptors at the apical surface of the RPE: one receptor, two functions / Emeline F. Nandrot, Yongen Chang, and Silvia C. Finnemann -- Implantation of mouse eyes with a subretinal microphotodiode array / Machelle T. Pardue [and others] -- Variation in the electroretinogram of C57BL/6 substrains of mouse / Alison L. Reynolds [and others] -- A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity / Janet R. Sparrow [and others] -- Endothelin receptors: do they have a role in retinal degeneration? / Vanesa Torbidoni, Mariá Iribarne, and Angela M. Suburo -- CNTF negatively regulates the phototransduction machinery in rod photoreceptors: implication for light-induced photostasis plasticity / Rong Wen [and others].

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This book is the result of The International Symposium on Retinal Degeneration which has become perhaps the most important research meeting in the field. The topics in this volume explore the etiology, cellular mechanisms, epidemiology, generics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early of congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories repor.

Retinal degeneration, Congresses.

Disease Models, Animal.

Genetic Therapy.

Photoreceptors.

Retinal Degeneration-- genetics.

Retinal Degeneration-- physiopathology.

Retinal Degeneration-- therapy.

Anderson, Robert E., (Robert Eugene)

Hollyfield, Joe G.

LaVail, Matthew M.

International Symposium on Retinal Degenerations(12th :2006 :, San Carlos de Bariloche, Argentina)

20171212125732.0

[Book]

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