Foreword: Early days of ion channels -- Electricity, nerves, batteries: a short history / Clay M. Armstrong -- Ion selectivity and conductance / Dorothy M. Kim, Jason G. McCoy, and Crina M. Nimigean -- Basic mechanisms of voltage sensing / Sandipan Chowdhury and Baron Chanda -- Ligand-dependent gating mechanism / William N. Zagotta -- Mechanosensitive channels and their emerging gating mechanisms / Sergei Suhkarev and Andriy Anishkin -- Patch clamping and single-channel analysis / León D. Islas -- Models of ion channel gating / Frank T. Horrigan and Toshinori Hoshi -- Utilizing Markov chains to model ion channel sequence variation and kinetics / Anthony Fodor -- Investigation of ion channel structure using fluorescence spectroscopy / Rikard Blunck -- A practical guide to solving the structure of an ion channel protein / Tahmina Rahman and Declan A. Doyle -- Structural study of ion channels by cyro-electron microscopy / Qiu-Xing Jiang and Liang Shi -- Rosetta structural modeling / Vladimir Yarov-Yarovoy -- Genetic methods for studying ion channel function in physiology and disease / Andrea L. Meredith -- Ion channel inhibitors / Jon Sack and Kenneth S. Eum -- High-throughput methods for ion channels / Haibo Yu and Min Li -- Voltage-gated sodium channels / William A. Catterall -- BK channels / Huanghe Yang and Jianmin Cui -- Inward rectifying potassium channels / Monica Sala-Rabanal and Colin G. Nichols -- Two-pore domain potassium channels / Leigh D. Plant and Steve A.N. Goldstein -- KCNQ channels / Nikita Gamper and Mark S. Shapiro -- Ionotropic glutamate receptors / Andrew Plested -- 5-HT₃ receptors / Sarah C.R. Lummis -- GABA[subscript A] receptors / Trevor G. Smart -- Cyclic nucleotide-gated channels / Michael D. Varnum and Gucan Dai -- Acid sensing ion channels / Cecilia Canessa -- Degenerin/ENaC channels / James D. Stockand -- TRPC channels / Jin-Bin Tian, Dhananjay Thakur, Yungang Lu, and Michael X. Zhu -- TRPV channels / Sharona E. Gordon -- TRPM channels / David D. McKemy -- TRMPL channels / Qiong Gao, Xiaoli Zhang, and Haoxing Xu -- CLC chloride channels and transporters / Giovanni Zifarelli and Michael Pusch -- Ca-activated chloride channels / Xiuming Wong and Lily Jan -- Store-operated CRAC channels / Murali Prakriya -- Mechanism of G-protein regulation of K⁺ channels / Rahul Mahajan and Diomedes E. Logothetis -- Calmodulin regulation of voltage-gated calcium channels and beyond / Manu Ben-Johny and David T. Yue -- Phosphorylation of voltage-gated ion channels / James S. Trimmer and Hiroaki Misonou -- Alternative splicing / Andrea L. Meredith -- Single transmembrane regulatory subunits of voltage-gated potassium channels / Anatoli Lvov and William R. Kobertz -- Ion channels of the heart / Donald M. Bers and Eleonora Grandi -- Ion channels in pain / J.P. Johnson, Jr. -- CLC-related proteins in diseases / Allan H. Bretag and Linlin Ma -- Cystic fibrosis and the CFTR anion channel / Yoshiro Sohma and Tzyh-Chang Hwang -- Drugs targeting ion channels / KeWei Wang