edited by C. Donald Combs, John A. Sokolowski, Catherine M. Banks
1 online resource
Wiley Series in modeling and simulation
Includes bibliographical references and index
The Vision: The Digital Patient-Improving Research, Development, Education, and Healthcare Practice -- The Digital Patient / C. Donald Combs -- Health, The Goal -- Personalized Medicine -- The Best Outcomes -- The Emergence of the Digital Patient -- The Human Physiome -- Enabling the Digital Patient -- P4 Medicine -- Conclusion -- References -- Reflecting on Discipulus and Remaining Challenges / Vanessa Díaz-Zuccarini, Mona Alimohammadi, César Pichardo-Almarza -- Introduction -- A Brief Contextual Background and a Call for Integration: Personalized Medicine is Holistic -- The Many Versions of the Digital Patient: On the Road to Medical Avatars -- Discipulus: The Digital Patient Technological Challenges and Main Conclusions -- The Remaining Challenges and Big Data -- Conclusion -- References -- Advancing the Digital Patient / Catherine M. Banks -- Introduction -- The Digital Patient: Its Early Start -- Engaging the Digital Patient -- Conclusion -- The Significance of Modeling and Visualization / John A. Sokolowski, Hector M. Garcia -- Introduction -- Modeling a Complex System: Human Physiology -- Medical Modeling, Simulation, and Visualization -- Modes and Types of Visualization -- Visualization for Patient-Specific Usefulness -- Conclusion -- References -- State of the Art: Systems Biology, the Physiome, and Personalized Health -- The Visible Human: A Graphical Interface for Holistic Modeling and Simulation / Victor M. Spitzer -- Introduction -- Education -- Modeling -- Virtual Reality Trainers and Simulators -- Conclusion -- References -- The Quantifiable Self: Petabyte by Petabyte / C. Donald Combs, Scarlett R. Barham -- Introduction -- Smarr's Quantified Self -- Extending Smarr's Research -- The Quantified Self-Vision, Simplified -- Criticism -- Conclusion -- References -- Systems Biology and Health Systems Complexity: Implications for the Digital Patient / C. Donald Combs, Scarlett R. Barham, Peter M. A. Shot -- Introduction -- Systems Biology -- The Institute for Systems Biology -- The Complexity Institute -- The Potential of Systems Biology -- Criticism -- Conclusion -- References -- Personalized Computational Modeling for the Treatment of Cardiac Arrhythmias / Seth H. Weinberg -- Introduction -- Basics of Cardiac Electrophysiology -- Cardiac Modeling Advancements -- Regulation of Intracellular Calcium -- From Cells to Cables to Sheets to Tissue to the Heart -- Where Can we go from Here? What is the Cardiac Model in the Digital Patient? -- References -- The Physiome Project, openEHR Archetypes, and the Digital Patient / David P. Nickerson, Koray Atalag, Bernard de Bono, Peter J. Hunter -- Introduction -- Multiscale Physiological Processes -- Physiome Project Standards, Repositories, and Tools -- Archetype Specialization -- Archetype Definition Language -- Linking Archetypes to External Knowledge Sources (Terminology and Biomedical Ontologies) -- Archetype Annotations -- OpenEHR Model Repository and Governance -- Fast Healthcare Interoperability Resources -- A Disease Scenario -- Summary and Conclusions -- References -- Physics-Based Modeling for the Physiome / William A. Pruett, Robert L. Hester -- Introduction -- Modeling Schemes -- Future Challenges -- Conclusion -- Acknowledgments -- References -- Modeling and Understanding the Human Body with SwarmScript / Sebastian von Mammen, Stefan Schellmoser, Christian Jacob, Jörg Hähner -- Introduction -- Related Work -- Multiagent Organization -- Designing Interactive Agents -- Speaking SwarmScript -- Answering Demand: The Design of SwarmScript -- Graph-Based Rule Representation -- The Source-Action-Target -- SwarmScript INT03D -- A SwarmScript Dialogue -- Discussion -- Summary -- References -- Using Avatars and Agents to Promote Real-World Health Behavior Changes / Sun Joo (Grace) Ann -- Introduction -- Avatars and Agents -- Using Agents and Avatars to Promote Health Behavior Changes -- Conclusion -- References -- Virtual Reality and Eating, Diabetes, and Obesity / Jessica E. Cornick, Jim Blascovich -- Introduction -- Virtual Reality -- Obesity and Weight Stigma -- Virtual Reality as a Tool for Combatting Health Issues -- Conclusion -- References -- Immersive Virtual Reality to Model Physical: Social Interaction and Self-Representation / Eric B. Bauman -- Introduction -- Theory for Immersive Virtual Learning Spaces -- Conclusion -- References -- Challenges: Assimilating the Comprehensive Digital Patient -- A Roadmap for Building a Digital Patient System / Saikou Y. Diallo, Christopher J. Lynch -- Introduction -- Approach -- Building the Digital Patient Through Interoperability -- Conclusion -- Acknowledgments -- References -- Multidisciplinary, Interdisciplinary, and Transdisciplinary Research: Contextualization and Reliability of the Composite / Andreas Tolk -- Introduction -- Interdisciplinarity and Interdisciplinary Research -- Data Engineering to Support Interdisciplinarity and Interoperability -- Base Object Models to Support Transdisciplinarity and Composability -- Open Challenges on Reliability -- Summary and Conclusion -- References -- Bayes Net Modeling: The Means to Craft the Digital Patient / Joseph A. Tatman, Barry C. Ezell -- Introduction -- Other Interesting Applications -- Conclusion -- References -- Potential Impact: Engaging The Digital Patient -- Virtual Reality Standardized Patients for Clinical Training / Albert Rizzo, Thomas Talbot -- Introduction -- The Rationale for Virtual Standardized Patients -- Conversational Virtual Human Agents -- Use Efforts to Create Virtual Standardized Patients -- Conclusion -- References -- The Digital Patient: Changing the Paradigm of Healthcare and Impacting Medical Research and Education / V. Andrea Parodi -- Introduction -- Overview Digital Medicine Projects -- Personalized Patient Care Clinical Use -- Recommended Education and Training for VPH Project Participation -- From Flexner to the 2010 Carnegie Report -- Summary Statements -- References -- The Digital Patient: A Vision for Revolutionizing the Electronic Medical Record and Future Healthcare / Richard M. Satava -- Introduction -- Applications of the Digital Patient as the EMR -- Discussion -- Conclusion -- References -- Realizing the Digital Patient / C. Donald Combs, John A. Sokolowski
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"Medical modeling and simulation technology is interdisciplinary and combines life and physical sciences, engineering, and medical expertise, and since it is being executed at various levels for various purposes at research and development institutions throughout the world, there exists the foremost challenge of conjoining these independent, yet complementary efforts to exploit their full potential. This is especially true with regard to the virtual human wherein there is the necessity to assimilate both the developed and developing components of the human physiome and diseaseome to advance patient care, medical practice, research and development, and education and training. This book advances personalized patient care using the virtual human and its ability to represent the human physiome (how the body functions) and diseaseome (disruptions to the body's functions). In order to achieve a holistic analysis of the body, this book provides an integrated, interoperable, i.e., complex and dynamic, examination of human biology with physiological and behavioral components of the overall patient experience. The future of healthcare is proving to be an overwhelming challenge globally, and changing practice to provide holistic, personalized care in an expanding (longer-lived and growing population) and demanding (multiple pathologies and needs per individual patient) environment requires optimizing research, technology, and training. Clinicians must exploit new generation capabilities in diagnostic and therapeutic patient care for the burden of patient needs to be met. Medical technology is very near to providing safe and effective personalized patient care through the use of virtual human technology, and via simulation, clinicians receive a virtual patient in real-time and conclude a more timely and precise treatment action. With contributions from international experts, the book presents the state-of-the-art in the development of the virtual human physiome in three areas: anatomical; physiological; and behavioral. This is followed by a discussion of current applications in: practice-personalized care; research; and education. With this two-fold research agenda aimed at assimilating the various resources needed to complete the virtual human, the book extends the integrated, interoperable capabilities to further research and development, augment education and training, and advance patient care"--Provided by publisher