عنوان

تاثیر عصاره‌ی اتانولی بر هیستوفیزیولوژی کلیه وپارامترهای بیوشیمایی سرم در رت های دیابتی نر

شماره

‭۱۶۰۵۵پ‬

زبان متن نوشتاري يا گفتاري و مانند آن

per

عنوان اصلي

تاثیر عصاره‌ی اتانولی بر هیستوفیزیولوژی کلیه وپارامترهای بیوشیمایی سرم در رت های دیابتی نر

نام نخستين پديدآور

/انصاری‌اوزی، ثریا

نام ناشر، پخش کننده و غيره

: علوم طبیعی

تاریخ نشرو بخش و غیره

، ‮‭۱۳۹۳‬

متن يادداشت

چاپی

جزئيات پايان نامه و نوع درجه آن

کارشناسی ارشد

نظم درجات

فیزیولوژی جانوری

زمان اعطا مدرک

‮‭۱۳۹۳/۱۱/۲۰‬

کسي که مدرک را اعطا کرده

تبریز

متن يادداشت

Diabetes Mellitus is the most prevalence disease by metabolic disorders and nearly to 250 million people was affected all over the world. High incidence of diabetes in particular the long-term complications such as its macrovasculary and microvasculary complications created heavy burden on health system. Diabetic nephropathy or renal damage is clinical syndrome that includes appearance albuminuria and proteinuria in the more advanced stages, and reduction of GFR. From primitive for treatment of diabetes and its complications, the use of herbal drugs has been customary. Nowadays, because of cheaper, less complications and more variable combinations, medicinal plants have more usage and opened a new view horizon of researches in this field. One of this plant with anti-diabetic property is Rosa canina (dog rose). The fruit of this plant is rich of useful and antioxidants compounds, that utilized wide spread level of diseases. Present study to investigating the effect of ethanolic extract of R. canina on renal histophysiology and some serum biochemical factors in diabetic rats. Materials and Methods: In this study thirty two (32) male Wistar rats weighting 180- 220 gr in 4 groups (control, diabetic control, diabetics + 250mg/kg/day extract, diabetics + 500 mg/kg/day extract) were used. Diabetes was induced by STZ (60mg/kg) intraperitoneal injection. The ethanolic extract of R. canina fruit with seeds is prepared of Soxhlet method. The period of experiment was 4 weeks. At the end of experiments, the rats were sacrificed and their serums collected for glucose, creatinine, urea and albumin estimation. Also the Kidney of all groups was sampled. Statistical analysis was performed using analysis of variance (one-way ANOVA). Results: The results showed that glucose, creatinine and urea concentrations were significantly increased in the diabetic group (p<0.05), while the serum albumin concentrations was reduced. The levels of glucose, creatinine and urea in treated groups decreased significantly in comparison with the diabetic control group (p<0.05). But albumin concentrations showed no significant changes (p>0.05). The changes of glucose in treatment groups showed no significant differences (p>0.05). Injection of STZ to diabetic group caused glomerulonephritis. Adminstrstion of ethanolic extract of Rosa canina at a dose of 250 mg/kg/day has no significant effect as compaired with diabetic control group, but adminstration high dose of this extract 500 mg/kg/day to bring forth improvement of glomerulonephritis in treated group. Discussion: The findings of previous studies on beneficial effects showed oral consumption of R. canina plant as plant with high antioxidant capacity and ability to accumulate free radicals. R. canina with reduction of lipid peroxidation and oxidative stress apply protective effects on the body's tissues. So, it can be concluded that oral administration of the ethanolic extract of R. canina significantly prevent from progress of disease and its complications by reduction of oxidative stress and inflammatory factors. This plant with anti-inflammatory properties, anti-oxidant and anti-diabetic property plays an important role in improving renal pathologies caused by diabetes

مستند نام اشخاص تاييد نشده

ثریاانصاری‌اوزی

مستند نام اشخاص تاييد نشده

بانان خجسته، سید مهدی، استاد راهنما

مستند نام اشخاص تاييد نشده

شیخ زاده حصاری، فرزام، استاد راهنما

مستند نام اشخاص تاييد نشده

دهقان، غلامرضا، استاد مشاور

مستند نام اشخاص تاييد نشده

محمدنژاد، فرزام، استاد مشاور

يادداشت عمومي

سیاه و سفید

وضعیت فهرست نویسی

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