Chemical analysis of some penicillin and cephalosporin drugs
نام عام مواد
[Thesis]
نام نخستين پديدآور
S. S. Yassin
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
King Fahd University of Petroleum and Minerals (Saudi Arabia)
تاریخ نشرو بخش و غیره
1991
مشخصات ظاهری
نام خاص و کميت اثر
179
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.S.
کسي که مدرک را اعطا کرده
King Fahd University of Petroleum and Minerals (Saudi Arabia)
امتياز متن
1991
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
This thesis describes work on the polarographic analysis of pencillin and cephalosporin antibiotics. Methods for the quantitative analysis of Ampicillin, Amoxycillin and Cephalexin were developed. These methods are based on the formation of Ni(II) or Co(II) complexes of the antibiotics or on degradation products namely, 2,5-diketopiperazine derivatives. The optimum conditions of buffering, support electrolyte, pH, temperature and the effect of time were studied for the Ni(II) complexes of Ampicillin and Amoxycillin. Under these optimum conditions, linear calibration ranges were usd5.00\times 10\sp{-7}usd to usd1.00\times 10\sp{-5}Musd and usd4.00\times 10\sp{-7}usd to usd2.00\times 10\sp{-5}Musd for Ampicillin and Amoxycillin respectively. Reversibility tests suggest that the electrode reactions are probably reversible and they are one electron transfer processes. The Co(II) complex of Cephalexin was compared with that of Ni(II) for the analysis and found to be inferior. A satisfactory method based on the formation of the 2,5-diketopiperazine derivatives of Amoxycillin was developed. The methods devised were tested on pharmaceutical products (capsules) and the results compared with pharmacopoeia methods. Good agreement was obtained.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Analytical chemistry
موضوع مستند نشده
Analytical chemistry
موضوع مستند نشده
Pharmacology
موضوع مستند نشده
Pure sciences
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )