عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TLpq303893126
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
A comparative study on measurement of Schistosoma mansoni transmission by coprologic and serologic techniques
نام عام مواد
[Thesis]
نام نخستين پديدآور
L. Chitsulo
نام ساير پديدآوران
B. L. Cline
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
Tulane University
تاریخ نشرو بخش و غیره
1990
مشخصات ظاهری
نام خاص و کميت اثر
120
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
Tulane University
امتياز متن
1990
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
The FAST-ELISA and modified Ritchie concentration technique were used in a comparative study assessing incidence of Schistosoma mansoni infection among children from Halaba, Egypt (HE), Kaundama, Malawi (KM), and Mtayangoma, Malawi (MM). FAST-ELISA had a sensitivity ranging from 90% to 100%. At HE, KM, and MM, seroprevalence (59.8%, 82.7%, and 89.9%, respectively) was higher (p < 0.001) than parasitologic prevalence (22.7%, 28.6%, and 54.3%, respectively). FAST-ELISA was more sensitive in detecting new infections than stool exam; "crude" serologic incidence rates were 11.9%, 47.1%, and 38.9%, compared with coprologic incidence rates of 4.2%, 11.9%, and 20% at HE, KM, and MM, respectively. 97% of stool conversions occurred in children who were seropositive on first exam, suggesting many were already infected but stool-negative before the transmission season. Only 0.5% (HE), 4.5% (KM), and 3.7% (MM) of stool-negative children had more than 4 eggs/g after conversion. Children who seroconverted had pretransmission geometric mean antibody (GMA) levels similar to stool-positive children, but higher (p < 0.030) than stool-negative children. Coprologic and serologic conversion:reversion ratios agreed with other measures of transmission. GMA level provided an indirect measure of intensity of infection and indication of transmission level within and between communities. GMA increased with geometric mean egg count (GMEC) among infected children at HE (r = 0.2896, p < 0.01) and MM (r = 0.3197, p < 0.01), but not at KM. Comparisons of GMA level, with either GMEC or stool prevalence indicated a significant correlation between GMA and the other 2 more conventional indices of infection. Within 10 days of treatment, GMA increased over pretreatment level (p = 0.00005) but fell to pretreatment level four months later in children who were still stool-positive. Among treated children, stool-negative four months posttreatment, GMA was lower than pretreatment level (p = 0.0037). FAST-ELISA provides an objective measure of incidence and a more convenient, rapid, and sensitive epidemiologic tool than stool examination for assessing schistosomiasis transmission.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Coprologic techniques
موضوع مستند نشده
Egypt
موضوع مستند نشده
Health and environmental sciences
موضوع مستند نشده
Immunology
موضوع مستند نشده
Malawi
موضوع مستند نشده
Public health
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
B. L. Cline
مستند نام اشخاص تاييد نشده
L. Chitsulo
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
