عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TLpq303947236
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
The effects of exercise on low-density-lipoprotein-receptor mediated clearance and atherosclerotic lesions in dietary induced hyperlipidemic NZW rabbits
نام عام مواد
[Thesis]
نام نخستين پديدآور
T. J. Pujol
نام ساير پديدآوران
R. C. Westerfield
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
The University of Alabama
تاریخ نشرو بخش و غیره
1991
مشخصات ظاهری
نام خاص و کميت اثر
89
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ed.D.
کسي که مدرک را اعطا کرده
The University of Alabama
امتياز متن
1991
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
The purpose of this study was to investigate the effect of regular exercise on LDL-receptor mediated clearance of plasma LDL. In addition, the study was designed to determine the effect of exercise on thoracic aorta stainable tissue lipids. The correlation between LDL-receptor mediated clearance and the extent of atherosclerotic lesions was also determined. Twenty New Zealand White rabbits were randomly assigned to exercise and sedentary groups. Identical environmental conditions existed for all subjects. After 12 weeks of daily physical exercise on a small animal treadmill, determination of LDL-receptor mediated clearance was performed. Fractional catabolic rate (FCR) was determined by injection of native I-LDL and methylated I-LDL. Native LDL is cleared by both receptor and non-receptor pathways, whereas methylated LDL is not recognized by the receptor. The difference between the disappearance rate of the two labeled species is the FCR. Subjects were anesthetized and a 50 millimeter segment of the thoracic aorta was removed for determination of atherosclerotic lesions. The atherosclerotic lesions were detected by staining the intima of the artery with Sudan IV. The total area stained was determined from enlarged photographs of the area and expressed as a percentage of the total aortic area inspected (% area involved). T-tests indicated no significant difference between exercise and sedentary groups for FCR at any of the first twelve hour samples. From 12 to 24 hours, the sedentary group FCR was significantly higher (p < 0.05) than the exercise group. T-tests showed exercise subjects had significantly lower (p < 0.05) atherosclerotic development in the aortic intima. No correlation was found to exist between FCR and % area involved. The results of this study indicate that exercise did not increase LDL-receptor mediated clearance. However, exercise did attenuate the development of atherosclerotic lesions. These findings indicate that exercise has an effect on atherosclerotic development beyond the control of plasma lipoprotein levels.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Anatomy & physiology
موضوع مستند نشده
Animals
موضوع مستند نشده
Biological sciences
موضوع مستند نشده
coronary disease
موضوع مستند نشده
Education
موضوع مستند نشده
Physical education
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
R. C. Westerfield
مستند نام اشخاص تاييد نشده
T. J. Pujol
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
