عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TLpq304036960
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Structure elucidation of bioactive constituents of two Indonesian medicinal plants
نام عام مواد
[Thesis]
نام نخستين پديدآور
L. B. S. Kardono
نام ساير پديدآوران
A. D. Kinghorn
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of Illinois at Chicago, Health Sciences Center
تاریخ نشرو بخش و غیره
1992
مشخصات ظاهری
نام خاص و کميت اثر
221
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
University of Illinois at Chicago, Health Sciences Center
امتياز متن
1992
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Through bioactivity-directed fractionation, six cytotoxic constituents have been characterized from the bark of Plumeria rubra L. collected in Bandung, Java, Indonesia. Three iridoids, fulvoplumierin, allamcin, and allamandin, as well as 2,5-dimethoxy-p-benzoquinone, were found to be active constituents of the P. rubra petroleum ether- and chloroform-soluble extracts. Cytotoxic compounds isolated from the water-soluble extract of the bark were the iridoid, plumericin, and the lignan, liriodendrin. Five additional iridoids, 15-demethylplumieride, plumieride, usd\alphausd-allamcidin, usd\betausd-allamcidin, 13-O-trans-p-coumaroyplumieride and the flavonoid glycoside, plumerubroside, were obtained as inactive constituents. Plumerubroside was found to be novel naturally occurring gallocatechin type flavan-3-ol glycoside to have been characterized. Five cytotoxic constituents have been isolated from the roots of Eurycoma longifolia Jack, collected in Samarinda, Indonesia. For canthin-6-one alkaloids, namely, 9-methoxycanthin-6-one, 9-methoxycanthin-6-one-N-oxide, 9-hydroxycanthin-6-one, 9-hydroxy-canthin-6-one-N-oxide, and one quassinoid, eurycomanone, were found to be cytotoxic principles. Two additional isolates, usd\betausd-carboline-1-propionic acid and 7-methoxy-usd\betausd-carboline-1-propionic acid were not significantly active against these cultured cells. However, eurycomanone and 7-methoxy-usd\betausd-carboline-1-propionic acid were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains. 9-Methoxycanthin-6-one-N-oxide,9-hydroxycanthin-6-one,9-hydroxycanthin-6-one-N-oxide and 7-methoxy-usd\betausd-carboline-1-propionic acid were established as being novel compounds. The structures of the isolates from P. rubra and E. longifolia were identified or elucidated through the use of some modern nmr technique, in addition to chemical methods.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Eurycoma longifolia
موضوع مستند نشده
Health and environmental sciences
موضوع مستند نشده
Pharmaceuticals
موضوع مستند نشده
Pharmacology
موضوع مستند نشده
Plumeria rubra
موضوع مستند نشده
Pure sciences
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
A. D. Kinghorn
مستند نام اشخاص تاييد نشده
L. B. S. Kardono
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
