عنوان

Spathodea Campanulata:

شماره

LA107945

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Spathodea Campanulata:

نام عام مواد

[Article]

ساير اطلاعات عنواني

Een Antidiabetisch Geneesmiddel?

نام نخستين پديدآور

Gert Laekeman

محل نشرو پخش و غیره

Leiden

نام ناشر، پخش کننده و غيره

Brill

متن يادداشت

Decoctions of the stem back of Spathodea campanulata (SC) are currently used in Rwanda to treat insulin- and non insulin-dependent diabetics. In order to confirm and farther examine hypoglycemic activity of this plant we set up a research project with as final objective a possible standardisation of Spathodea in antidiabetic therapy in Rwanda. Up to now we were able to confirm the blood sugar lowering effect of SC in hyperglycemic mice (hyperglycemia provoked by streptozotocin = SZ). Also hyperglycemia in glucose loaded mice (glucose tolerance test = GTT) could be tempered by SC. Despite these clearcut hypoglycemic activity, no rise of insulin was seen in the SC treated mice. The activity must be due to some other mechanism of action. The search for active principles did not lead to satisfying results up to now. We have only indirect evidence for the presence of sugar-like compounds, as SC decoctions enhance the glycemia transiently. Some hypotheses are formulated with regard to mechanisms of action and active compounds of SC. These aspects will guide future research. Decoctions of the stem back of Spathodea campanulata (SC) are currently used in Rwanda to treat insulin- and non insulin-dependent diabetics. In order to confirm and farther examine hypoglycemic activity of this plant we set up a research project with as final objective a possible standardisation of Spathodea in antidiabetic therapy in Rwanda. Up to now we were able to confirm the blood sugar lowering effect of SC in hyperglycemic mice (hyperglycemia provoked by streptozotocin = SZ). Also hyperglycemia in glucose loaded mice (glucose tolerance test = GTT) could be tempered by SC. Despite these clearcut hypoglycemic activity, no rise of insulin was seen in the SC treated mice. The activity must be due to some other mechanism of action. The search for active principles did not lead to satisfying results up to now. We have only indirect evidence for the presence of sugar-like compounds, as SC decoctions enhance the glycemia transiently. Some hypotheses are formulated with regard to mechanisms of action and active compounds of SC. These aspects will guide future research.

تاريخ نشر

1992

توصيف ظاهري

131-144

عنوان

Afrika Focus

شماره جلد

8/2

شماره استاندارد بين المللي پياييندها

2031-356X

اصطلاح موضوعی

diabetes

اصطلاح موضوعی

hypoglycemic activity

اصطلاح موضوعی

Rwanda

اصطلاح موضوعی

Spathodea campanulata

مستند نام اشخاص تاييد نشده

Gert Laekeman

شماره بازیابی

10.1163/2031356X-00802004

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Article]

کد کاربرگه

275578

سطح دسترسي

a

تكميل شده

Y