عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL57987
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
The Efficacy of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Men and Women with Heart Failure with Reduced Ejection Fraction
نام عام مواد
[Thesis]
نام نخستين پديدآور
Wali, Muhammad Ahmer
نام ساير پديدآوران
Pilote, Louise
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
McGill University (Canada)
تاریخ نشرو بخش و غیره
2020
يادداشت کلی
متن يادداشت
79 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.Sc.
کسي که مدرک را اعطا کرده
McGill University (Canada)
امتياز متن
2020
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Background. Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are essential to the treatment of heart failure with reduced ejection fraction (HFrEF). However, little data are available to determine whether their efficacy in reducing hospitalizations and mortality may differ between men and women with HFrEF. Purpose. To explore whether differences exist in the efficacy of ACEi/ARBs in HFrEF by sex. Methods. We conducted a pooled analysis of individual data from 4 randomized clinical trials: The Study of Left Ventricular Dysfunction (SOLVD) Treatment, SOLVD Prevention, Candesartan in Heart Failure: Assessment of Morbidity and Mortality (CHARM) Alternative and Added trials. The primary outcome was a composite of death or hospitalization for heart failure. Multivariable analyses were conducted using Cox proportional hazards models, adjusting for confounders, to obtain sex specific hazard ratios (HRs) and the interaction was tested by a sexby- randomized treatment term. Results. Among the 11,373 participants (19% women; mean age 61.5), women were older, with a higher prevalence of type 2 diabetes and hypertension, and a lower prevalence of ischemic heart disease than men regardless of treatment group. The ACEi/ARBs group had a lower incidence of the primary outcome compared to placebo [13.3 vs 16.6 per 100 person-year], with a similar efficacy in both men and women [adjusted-HR men 0.76 vs women 0.88, p-sex-by-drug interaction = 0.12]. However, women were more likely than men to be hospitalized for HF despite treatment [adjusted-HR men 0.65 95%CI 0.54-0.79 vs women 0.82 95%CI 0.74-0.90, p-sex-by-drug interaction = 0.09]. Conclusions. The association between ACEi/ARB and the primary outcome of death or HF hospitalization did not differ between men and women. However, women were more likely than men to have HF hospitalizations despite ACEi/ARB treatment. Future trials should include a larger enough sample size of women and men to enable sex-specific recommendations about HF drug efficacy.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Drug interactions
اصطلاح موضوعی
Ejection fraction
اصطلاح موضوعی
Enzymes
اصطلاح موضوعی
Epidemiology
اصطلاح موضوعی
Gender differences
اصطلاح موضوعی
Heart failure
اصطلاح موضوعی
Hospitalization
اصطلاح موضوعی
Hypertension
اصطلاح موضوعی
Manuscripts
اصطلاح موضوعی
Morbidity
اصطلاح موضوعی
Mortality
اصطلاح موضوعی
Women
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Wali, Muhammad Ahmer
نام شخص - ( مسئولیت معنوی درجه دوم )
مستند نام اشخاص تاييد نشده
Pilote, Louise
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
McGill University (Canada)
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
