Development and In-Silico Evaluation of a Closed-Loop Fluid Resuscitation Control Algorithm with Mean Arterial Pressure Feedback
نام عام مواد
[Thesis]
نام نخستين پديدآور
Alsalti, Mohammad Salahaldeen Ahmad
نام ساير پديدآوران
Hahn, Jin-Oh
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of Maryland, College Park
تاریخ نشرو بخش و غیره
2020
يادداشت کلی
متن يادداشت
86 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.S.
کسي که مدرک را اعطا کرده
University of Maryland, College Park
امتياز متن
2020
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
In this thesis, a model-based closed-loop fluid resuscitation controller using mean arterial pressure (MAP) feedback is designed and later evaluated on an in-silico testbed. The controller is based on a subject specific model of blood volume and MAP response to fluid infusion. This simple hemodynamic model is described using five parameters only. The model was able to reproduce blood volume and blood pressure response to fluid infusion using an experimental dataset collected from 23 sheep and is therefore suitable to use for control design purposes. A model-reference adaptive control scheme was chosen to account for inter-subject variability captured in the parametric uncertainties of the underlying physiological model. Three versions of the control algorithm were studied under different measurement availability scenarios. In-silico evaluation of the three controllers was done using a comprehensive cardiovascular physiology model on a cohort of 100 virtually generated patients. Results clearly show that a tradeoff exists between tracking and estimation performance depending on measurement availability.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Biomedical engineering
اصطلاح موضوعی
Fluid mechanics
اصطلاح موضوعی
Mechanical engineering
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )