Enhanced Optical Tomography in Diffuse Media Using Optical Gating of Early Photons
نام عام مواد
[Thesis]
نام نخستين پديدآور
Ghosh, Aishwarya
نام ساير پديدآوران
Tichauer, Kenneth M.
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
Illinois Institute of Technology
تاریخ نشرو بخش و غیره
2020
يادداشت کلی
متن يادداشت
58 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.S.
کسي که مدرک را اعطا کرده
Illinois Institute of Technology
امتياز متن
2020
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Tissue biopsies, where a volume of tissue is removed from a patient, typically through needle extraction, provides critical information about the cellular and molecular aspects of an individual patient's health and/or disease. However, current pathological assessments of tissue biopsies evaluate less than 1% of the volume of the tissue (e.g., one to a few 5-micron slices are sectioned out of the biopsy and stained/processed for microscopic analysis). Since the bulk of tissue biopsy is carried out through optical imaging (absorption or fluorescence), a more 3D, "whole-biopsy" view is conceivably possible with optical projection tomography (OPT). The challenge with OPT has been that for clinically relevant sized biopsies, most photons undergo multiple scattering events that lead to loss of spatial resolution that makes accurate pathological analysis intractable. In my MS thesis, I worked on the development of an enhanced OPT system that employs optical gating based on non-linear up-conversion of infrared ultrashort laser pulses to isolate "early-arriving" photons that experience significantly less scatter than the bulk of photons transiting a scattering biological sample. Considering the complexity of such a system, the entirety of my MS thesis work was spent constructing and testing the femtosecond optical gated OPT system and though I was unable to validate its operation in biological samples, simulations suggest that the properties we were able to achieve could allow high resolution optical imaging in 0.1-1 cm-diameter specimens.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Bioengineering
اصطلاح موضوعی
Engineering
اصطلاح موضوعی
Optics
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )