عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL51958
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
In-Vitro Diffusion Studies to Develop and Evaluate Various Semisolid Bases to Optimize Clotrimazole Release with Reduced Level of Drug
نام عام مواد
[Thesis]
نام نخستين پديدآور
Zahid, Zahidul Islam
نام ساير پديدآوران
Babar, Almas
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
Long Island University, The Brooklyn Center
تاریخ نشرو بخش و غیره
2019
يادداشت کلی
متن يادداشت
111 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.S.
کسي که مدرک را اعطا کرده
Long Island University, The Brooklyn Center
امتياز متن
2019
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
This study was undertaken to develop and evaluate various dermatological formulations with optimum drug release and clinical efficacy. Formulations containing 0.5% of Clotrimazole were developed using HPMC gel, cationic and non-ionic emulsion based vehicles. Penetration enhancers including dimethylsulfoxide (DMSO), polyethylene glycol (PEG) and diethylene glycol monoethyl ether (DGME) at various levels were studied. Diffusion studies were carried out with Franz Diffusion Cells. Using a commercial product as a control, all samples were screened on an equal sample weight basis for the drug release through the cellulose membrane. The formulation with the best release pattern was then compared against the commercial product containing I% of the drug and was evaluated using the human cadaver skin. The general order of drug release from three different vehicles was observed in this following order: HPMC Gel> Cationic Emulsion> Non-Ionic Emulsion system. Among all samples with 0.5% of clotrimazole, the HPMC Gel with 15% DMSO gave the maximum release, where the sample exhibited 8.07% drug release compared to the 4.93% drug release from the control formulation after 2 hour of study period using the Franz Diffusion Cell. This formulation was then further studied using human cadaver skin as a diffusion barrier over a period of 12 hour against a commercial product. Here, the drug release was observed to be 12.62% from the sample and 4.05% from the brand name formulation. This represents greater than 3 folds increase in the drug release while compared against the marketed formulation. This data was also used to calculate various physicochemical parameters that influence drug diffusion.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Pharmaceutical sciences
اصطلاح موضوعی
Pharmacology
اصطلاح موضوعی
Wildlife conservation
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Zahid, Zahidul Islam
نام شخص - ( مسئولیت معنوی درجه دوم )
مستند نام اشخاص تاييد نشده
Babar, Almas
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
Long Island University, The Brooklyn Center
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
