Rabies Genetic Diversity and Reservoir Identification in Terrestrial Carnivores Throughout Ethiopia
نام عام مواد
[Thesis]
نام نخستين پديدآور
Binkley, Laura Elyse
نام ساير پديدآوران
Gebreyes, Wondwossen
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
The Ohio State University
تاریخ نشرو بخش و غیره
2019
يادداشت کلی
متن يادداشت
350 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
The Ohio State University
امتياز متن
2019
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Ethiopia has long been among the most rabies-affected countries in the world with an annual incidence rate of 1.6/100,000 population. Domestic dogs serve as the principal reservoir for rabies transmission however, little information exists regarding the genetic diversity of RABVs circulating in dogs or the existence of cycles maintained by other mammalian species. Identifying all reservoirs of rabies plays a crucial role in effective disease control. Objectives include 1.) Investigation of the genetic diversity of rabies circulating in wild and domestic species throughout Ethiopia; 2.) Identification of intraspecies and interspecies contact rates at communal foraging sites; 3.) Application of contact rate estimates to mathematical expressions that will help determine maintenance potential. This work comprises the study of 230 partial and complete N-gene sequences obtained from both wild and domestic species collected throughout different regions of Ethiopia during the period 2010-2017. Camera traps were used to examine contact rates within and between terrestrial carnivore species at communal foraging sites. These contact rates were then applied to expressions of the basic reproductive number to determine the rabies maintenance potential of populations. Results identified the existence of a major dog rabies epizootic throughout Ethiopia involving a homogeneous RABV variant that has been spreading from an epicenter in the Oromia region. Additionally, a 3.3% divergent RABV variant circulating in side-stripped jackals was identified. Intraspecies contact rates and calculations of maintenance potential were highest in domestic dogs followed by spotted hyenas and domestic cats, respectively. Interspecies contact rates and calculations of maintenance potential were highest between domestic cats and spotted hyenas. This snapshot of rabies dynamics in Ethiopia provides important baseline data for prevention and control efforts and serves as the first steps in identifying wildlife reservoir hosts for rabies transmission throughout the country.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Animal diseases
اصطلاح موضوعی
Biology
اصطلاح موضوعی
Ecology
اصطلاح موضوعی
Environmental health
اصطلاح موضوعی
Environmental studies
اصطلاح موضوعی
Epistemology
اصطلاح موضوعی
Health sciences
اصطلاح موضوعی
Public health
اصطلاح موضوعی
Wildlife management
اصطلاح موضوعی
Zoology
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )