عنوان

Exploring the Role of Rheology in Bolus Flow Using an in-vitro Approach

شماره

TL51574

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Exploring the Role of Rheology in Bolus Flow Using an in-vitro Approach

نام عام مواد

[Thesis]

نام نخستين پديدآور

Waqas, Muhammad

نام ناشر، پخش کننده و غيره

Chalmers Tekniska Hogskola (Sweden)

تاریخ نشرو بخش و غیره

2019

متن يادداشت

83 p.

جزئيات پايان نامه و نوع درجه آن

Ph.D.

کسي که مدرک را اعطا کرده

Chalmers Tekniska Hogskola (Sweden)

امتياز متن

2019

متن يادداشت

Swallowing disorders, termed 'dysphagia', are more common in the elderly but can also affect younger persons. Approximately, 8% of the world's population suffers from dysphagia. A Texture Modified Diet (TMD), which increases bolus viscosity to adjust for the sluggish bolus handling mechanism, is the most common intervention. Other rheological properties, such as bolus elasticity, shear rate, and yield stress, are often ignored. TMDs, which often comprise gum- and starch-based thickeners, were characterized for their rheological properties. The gum-based thickeners were considerably more elastic and exhibited a mild yield stress, showing a fine-stranded network structure on the nanoscale length when visualised by electron microscopy, as compared to the starch-based thickeners. Among the rheological properties, elasticity is cited as the most important for safe swallowing. Therefore, an in vivo study was performed in which fluids that have elastic properties were assessed for efficacy of safe swallowing in patients with dysphagia. These fluids showed easy swallow ability, in terms of the sensory response and transit times during the oral and pharyngeal stages. While clinical examination is the standard and most appropriate way to diagnose dysphagia, difficulties arise in relation to the use of contrast media, ethics, and patient discomfort. To overcome these difficulties and to reduce the frequency of clinical analysis, an in vitro approach was adopted. And an in vitro swallowing model was developed that can be used to perform experimental bolus visualisation and manometry, mimicking the in vivo counterpart of video fluoroscopy and manometry. To study bolus transport, Pulsed Ultrasound Doppler Velocimetry was used. Pressure sensors were embedded in the model pharynx body to measure the bolus pressure during transit. The device delivers the bolus, at an appropriate speed and volume, and can handle boluses with different consistencies. In the device, bolus velocities ranging from 0.04 m/s to 0.48 m/s were measured, while bolus consistency was varied from nectar-thick to pudding-thick following National Dysphagia Diet scale. These velocities are within the range that is often reported for in vivo experiments. The acquired velocities yielded shear rates in the range of 13-229 s-1, which is both lower and mostly higher shear rates than 50s-1 commonly referred to for deglutition. Similarly, when gum and starch-thickened boluses were injected into the model pharynx, the starch-thickened bolus often disintegrated, leaving residues in the model pharynx. When thickened boluses were analysed using manometry, by varying the bolus composition, shape, and volume, the pressure values at different locations in the model pharynx were in the range often noticed in clinical assessments. The device can simulate abnormal swallowing conditions, such as delayed epiglottis and Upper Esophageal Sphincter (UES) closure. Simulations of abnormal UES conditions, i.e. reduced UES area, yielded different pressure values in the lower pharynx. Therefore, the device can be used as a pre-clinical study tool to elucidate the relationship between bolus rheology and deglutition.

اصطلاح موضوعی

Chemical engineering

اصطلاح موضوعی

Industrial engineering

مستند نام اشخاص تاييد نشده

Waqas, Muhammad

مستند نام تنالگان تاييد نشده

Chalmers Tekniska Hogskola (Sweden)

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y