عنوان

Quantitative drug design :

شابک

1420070991

شابک

9781420070996

شماره

b766688

عنوان اصلي

Quantitative drug design :

نام عام مواد

[Book]

ساير اطلاعات عنواني

a critical introduction /

نام نخستين پديدآور

Yvonne Connolly Martin.

وضعيت ويراست

2nd ed.

محل نشرو پخش و غیره

Boca Raton :

نام ناشر، پخش کننده و غيره

CRC Press/Taylor & Francis,

تاریخ نشرو بخش و غیره

©2010.

نام خاص و کميت اثر

xv, 282 pages :

ساير جزييات

illustrations ;

ابعاد

25 cm

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Overview of quantitative drug design -- Noncovalent interactions in biological systems -- Preparation of 3D structures of molecules for 3D QSAR -- Calculating physical properties of molecules -- Biological data -- Form of equations that relate potency and physical properties -- Statistical basis of regression and partial least-squares analysis -- Strategy for the statistical evaluation of a data set of related molecules -- Detailed examples of QSAR calculations on erythromycin esters -- Case studies -- Methods to approach other structure-activity problems.

بدون عنوان

0

متن يادداشت

"Incorporating the novel developments that have occurred in this field since the publication of the first edition, Quantitative Drug Design: A Critical Introduction, Second Edition shows scientists how to apply quantitative structure-activity relationship (QSAR) techniques at a state-of-the-art level. It presents computational methods that analyze the relationships between molecular structure and biological activity, emphasizing techniques that provide a quantitative forecast of biological potency." "Based on the author's four decades of experience in all areas of ligand-based computer-assisted drug design, this invaluable book describes how to transform ligand structure-activity relationships into models that predict the potency or activity/inactivity of new molecules. It discusses the physical chemistry of ligand-macromolecule interactions and the computer programs that translate a molecule's potential to participate in these interactions into interpretable quantitative descriptors. The book also covers the fundamentals of multivariate statistics and validation procedures needed to support a valid structure-activity model."--BOOK JACKET.

موضوع مستند نشده

Drugs-- Design.

موضوع مستند نشده

Drugs-- Structure-activity relationships.

موضوع مستند نشده

QSAR (Biochemistry)

موضوع مستند نشده

Biopharmaceutics.

موضوع مستند نشده

Drug Design.

موضوع مستند نشده

Models, Theoretical.

موضوع مستند نشده

Quantitative Structure-Activity Relationship.

موضوع مستند نشده

Drugs-- Design.

موضوع مستند نشده

Drugs-- Structure-activity relationships.

موضوع مستند نشده

QSAR (Biochemistry)

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Martin, Yvonne Connolly,1936-

تاريخ عمليات

20201206115752.0

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y