عنوان

Preclinical drug development /

شابک

157444882X

شابک

9781574448825

شماره

b727360

عنوان اصلي

Preclinical drug development /

نام عام مواد

[Book]

نام نخستين پديدآور

[edited by] Mark C. Rogge, David R. Taft.

محل نشرو پخش و غیره

Boca Raton :

نام ناشر، پخش کننده و غيره

Taylor & Francis,

تاریخ نشرو بخش و غیره

2005.

نام خاص و کميت اثر

xiv, 575 pages :

ساير جزييات

illustrations ;

ابعاد

23 cm.

عنوان فروست

Drugs and the pharmaceutical sciences ;

مشخصه جلد

v. 152

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

The scope of preclinical drug development: an introduction and framework / Mark C. Rogge -- Interspecies differences in physiology and pharmacology: extrapolating preclinical data to human populations / Marilyn N. Martinez -- Transgenic animals for preclinical drug development / Li-Na Wei -- Pharmacokinetics/ADME of small molecules / Vangala V. Subrahmanyam and Alfred P. Tonelli -- Pharmacokinetics/ADME of large molecules / Rene Braeckman -- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / Paolo Vicini and Peter L. Bonate -- Formulation and route of administration -- influencing drug permeability and absorption / Mansoor A. Khan and Fakhrul Ahsan -- Assessment of pharmacokinetics and drug activity: isolated organ systems and the membrane transporter family / Kevin R. Sweeney and David R. Taft -- alternate methods for assessing absorption, metabolism, and routes of elimination / Peter Bullock -- Toxicity evaluations: ICH guidelines and current practice / Jeffrey L. Larson -- Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice -- Principles of toxicogenomics: implications for preclinical drug development / Jürgen Borlak -- Utilizing the preclinical database to support clinical drug development / Howard Lee.

بدون عنوان

0

متن يادداشت

"This reference discusses in detail the broad realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology through the regulatory expectations that support clinical trials. Providing chapters on pharmacokinetics, modeling and simulation, formulation and routes of administration, toxicity evaluations, the assessment of drug absorption and metabolism, and interspecies scaling, this guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences."--Jacket.

موضوع مستند نشده

Drug development.

موضوع مستند نشده

Drug Evaluation, Preclinical-- methods.

موضوع مستند نشده

Drug Industry-- methods.

موضوع مستند نشده

Médicaments-- Développement.

موضوع مستند نشده

Arzneimittelentwicklung

موضوع مستند نشده

Drug development.

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

شماره رده

نشانه اثر

نشانه اثر

مستند نام اشخاص تاييد نشده

Rogge, Mark C.

مستند نام اشخاص تاييد نشده

Taft, David R.

تاريخ عمليات

20201213235749.0

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y