عنوان

Reversal of Warfarin-Induced Hemorrhage in the Emergency Department

شماره

LA12f3z5c9

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Reversal of Warfarin-Induced Hemorrhage in the Emergency Department

نام عام مواد

[Article]

نام نخستين پديدآور

Zareh, Meena; Davis, Andrew J; Henderson, Sean O

متن يادداشت

Warfarin, an oral vitamin K antagonist, is used to prevent arterial and venous thromboembolism in patients suffering from a multitude of diseases. In 2004, 31 million warfarin prescriptions were dispensed in the United States. Warfarin inhibits the activation of the vitamin K-dependent clotting factors (Factors II, VII, IX, and X) and regulatory proteins (proteins C, S, and Z). It is one of the leading drugs implicated in emergency room visits for adverse drug reactions. Annually the frequency of bleeding complications associated with overanticoagulation is 15% to 20%, with fatal bleeds measuring as high as 1% to 3%. The most effective method of warfarin reversal involves the use of Four Factor Prothrombin Complex Concentrate (PCC), which is widely used throughout Europe but is unavailable in the United States. The current therapies available to emergency room physicians in the United States are fresh frozen plasma, recombinant Factor VIIa (rFVIIa), Factor Eight Inhibitory Bypassing Activity, or Three Factor PCC concomitantly administered with vitamin K. We review the advantages and disadvantages of these therapies and recommend Three Factor PCC with small doses of rFVIIa and with vitamin K in life-threatening situations if Four Factor PCC is unavailable. [West J Emerg Med. 2011;12(4):386-392.]

تاريخ نشر

2011

عنوان

Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health

شماره جلد

12/4

عنصر شناسه اي

Zareh, Meena; Davis, Andrew J; Henderson, Sean O

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

275578

سطح دسترسي

a

تكميل شده

Y