عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
LA74d2c80k
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
The Aging Brain: Are two pathologies worse than one? White matter hyperintensities, beta-amyloid, and cognition in normal elderly
نام عام مواد
[Article]
نام نخستين پديدآور
Onami, Susan
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
White matter hyperintensities (WMH)-areas of increased signal on T2 and Fluid Attenuated Inversion Recovery (FLAIR) MRI images-and beta-amyloid (ABeta) plaques-an Alzheimer's disease pathology-are commonly found in the brains of cognitively normal elderly people. Although previous studies have looked at these pathologies, the interaction between them remains unclear. This study investigated the potential of WMH and ABeta burden in predicting cognition in normal elderly. FLAIRs of 45 local elderly participants were used to quantify WMH volumes to determine WMH load; and a Pittsburg Compound B (PIB) index obtained with positron emission tomography (PET) was used as a measure of ABeta burden. Hierarchical regressions of WMH volume and PIB group predicting executive function, working memory, and episodic memory were done. Results showed a trend towards a WMH and PIB interaction with episodic memory, suggesting that WMH and ABeta burden together may cause worse episodic memory than either of those pathologies by itself. Additionally, we found that education may be modulating the effects of WMH on executive function.
مجموعه
تاريخ نشر
2010
عنوان
Berkeley Scientific Journal
شماره جلد
13/2
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
عنصر شناسه اي
Onami, Susan
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب اطلاعات رکورد کتابشناسی
نوع ماده
[Article]
کد کاربرگه
275578
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
