عنوان

The effect of comorbidities on overall mortality in Stevens- Johnson Syndrome: an analysis of the Nationwide Inpatient Sample

شماره

LA9333c5dw

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

The effect of comorbidities on overall mortality in Stevens- Johnson Syndrome: an analysis of the Nationwide Inpatient Sample

نام عام مواد

[Article]

نام نخستين پديدآور

Ezaldein, Harib; Totonchy, Mariam; Chow, Christopher; Samuel, Andre; Ventura, Alessandra

متن يادداشت

Background: Stevens Johnson Syndrome (SJS) is a lifethreateningskin condition with an overall mortalityrate of 5%. Although the causes and pathologyof the disease have been well studied, the factorsthat significantly contribute to mortality remainunclear. Objective: To determine relevant risk factorsthat increase the likelihood of inpatient mortalityafter diagnosis of SJS. Methods: A retrospectivecohort study of the 2010-2011 Healthcare Costsand Utilization Project (HCUP) Nationwide InpatientSample (NIS) database was conducted. This studyincluded 1,811 patients who encountered inpatienthospital stays with a discharge diagnosis of SJS.Results: The primary outcome of our study was inhospitalmortality. We analyzed the prevalence andassociated inpatient mortality of underlying criticalillness in patients with SJS. Three age ranges ofpatients in this study showed significantly increasedrates of inpatient mortality by odds-ratio with a 95%CI: 70-79 years (10.91% mortality, OR=4.57, p=0.001),80-89 years (10.67% mortality, OR=4.48, p=0.001), and90+ years (9.30% mortality, OR=4.22, p=0.028). Twocomorbid conditions showed significant associationwith increased inpatient mortality in SJS by odds-ratiowith a 95% CI: cirrhosis (14.58% mortality, OR=2.79,p=0.028) and metastatic disease (10.62% mortality,OR=1.87, p=0.031). Interpretation: Age (70+ years),cirrhosis, and metastatic disease were identified assignificantly associated with inpatient mortality afterdiagnosis with SJS. These findings enhance currentunderstanding of the pathology of this disease, aswell as help improve clinical management of high-riskpatients to reduce inpatient mortality.

تاريخ نشر

2017

عنوان

Dermatology Online Journal

شماره جلد

23/4

عنصر شناسه اي

Ezaldein, Harib; Totonchy, Mariam; Chow, Christopher; Samuel, Andre; Ventura, Alessandra

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

275578

سطح دسترسي

a

تكميل شده

Y