عنوان

Gender-specific gene-environment interaction in alcohol dependence:

شماره

LA05g1k3mm

عنوان اصلي

Gender-specific gene-environment interaction in alcohol dependence:

نام عام مواد

[Article]

نام نخستين پديدآور

Perry, Brea L; Pescosolido, Bernice A; Bucholz, Kathleen; Edenberg, Howard; Kramer, John; Kuperman, Samuel; Schuckit, Marc Alan

عنوان اصلي به قلم نويسنده ديگر

the impact of daily life events and GABRA2.

متن يادداشت

Gender-moderated gene-environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testing two- and three-way interactions between these variables using multi-level regression models fit to data from 2,281 White participants in the Collaborative Study on the Genetics of Alcoholism. Significant direct effects of variables of interest were identified, as well as gender-specific moderation of genetic risk on this SNP by social experiences. Higher levels of positive life events were protective for men with the high-risk genotype, but not among men with the low-risk genotype or women, regardless of genotype. Our findings support the disinhibition theory of alcohol dependence, suggesting that gender differences in social norms, constraints and opportunities, and behavioral undercontrol may explain men and women's distinct patterns of association.

تاريخ نشر

2013

عنوان

UC San Diego

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

275578

سطح دسترسي

a

تكميل شده

Y