عنوان

Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

پدید آورنده

Rollins, Brandi; Martin, Maureen V.; Sequeira, P. Adolfo; Moon, Emily A.; Morgan, Ling Z.; Watson, Stanley J.; Schatzberg, Alan; Akil, Huda; Myers, Richard M.; Jones, Edward G.; Wallace, Douglas C.; Bunney, William E.; Vawter, Marquis P.

موضوع

رده

کتابخانه

مرکز و کتابخانه مطالعات اسلامی به زبان‌های اروپایی

محل استقرار

استان: قم ـ شهر: قم

تماس با کتابخانه : 32910706-025

شماره کتابشناسی ملی

شماره

LA2bv9x539

عنوان و نام پديدآور

عنوان اصلي

Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

نام عام مواد

[Article]

نام نخستين پديدآور

Rollins, Brandi; Martin, Maureen V.; Sequeira, P. Adolfo; Moon, Emily A.; Morgan, Ling Z.; Watson, Stanley J.; Schatzberg, Alan; Akil, Huda; Myers, Richard M.; Jones, Edward G.; Wallace, Douglas C.; Bunney, William E.; Vawter, Marquis P.

یادداشتهای مربوط به خلاصه یا چکیده

متن يادداشت

BackgroundMitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA (mtDNA) sequence have been reported in SZ and BD patients.Methodology/Principal FindingsDorsolateral prefrontal cortex (DLPFC) from a cohort of 77 SZ, BD, and MDD subjects and age-matched controls (C) was studied for mtDNA sequence variations and heteroplasmy levels using Affymetrix mtDNA resequencing arrays. Heteroplasmy levels by microarray were compared to levels obtained with SNaPshot and allele specific real-time PCR. This study examined the association between brain pH and mtDNA alleles. The microarray resequencing of mtDNA was 100% concordant with conventional sequencing results for 103 mtDNA variants. The rate of synonymous base pair substitutions in the coding regions of the mtDNA genome was 22% higher (p = 0.0017) in DLPFC of individuals with SZ compared to controls. The association of brain pH and super haplogroup (U, K, UK) was significant (p = 0.004) and independent of postmortem interval time.ConclusionsFocusing on haplogroup and individual susceptibility factors in psychiatric disorders by considering mtDNA variants may lead to innovative treatments to improve mitochondrial health and brain function.

مجموعه

تاريخ نشر

2009

عنوان

UC Irvine

دسترسی و محل الکترونیکی

نام الکترونيکي

اطلاعات رکورد کتابشناسی

نوع ماده

[Article]

کد کاربرگه

275578

اطلاعات دسترسی رکورد

سطح دسترسي

تكميل شده

عنوان Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

پدید آورنده Rollins, Brandi; Martin, Maureen V.; Sequeira, P. Adolfo; Moon, Emily A.; Morgan, Ling Z.; Watson, Stanley J.; Schatzberg, Alan; Akil, Huda; Myers, Richard M.; Jones, Edward G.; Wallace, Douglas C.; Bunney, William E.; Vawter, Marquis P.