عنوان

Nutrient Modulators of Inflammation in Obese and Lean Adolescents

شماره

TL2m36n069

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Nutrient Modulators of Inflammation in Obese and Lean Adolescents

نام عام مواد

[Thesis]

نام نخستين پديدآور

King, Emily Clark

نام ساير پديدآوران

Elashoff, Robert M

نام ناشر، پخش کننده و غيره

UCLA

تاریخ نشرو بخش و غیره

2017

کسي که مدرک را اعطا کرده

UCLA

امتياز متن

2017

متن يادداشت

Background: Obese individuals are at risk for iron deficiency due to both insufficient dietary iron intake and trapping of iron through an interleukin-6 (IL-6) dependent pathway. Vitamin D deficiency, which is also common in obese individuals, contributes to the pro-inflammatory state of obesity. Obese individuals are also at increased risk for insulin resistance, which may be worsened by iron and vitamin D deficiency. Objective: To evaluate the associations of, and interaction between, iron and vitamin D with inflammation and insulin resistance.Design/Methods: 19 obese (BMI Z-score  2.0) and 28 lean (BMI Z-score -2.0 to 1.0) subjects were recruited (mean age 14.5 years, SD 2.1 years) in a cross-sectional study. Fasting serum was analyzed for iron status [soluble transferrin receptor (sTfR)], IL-6, and 25-hydroxy vitamin D (25[OH]D). Insulin sensitivity (Si) was determined by frequently sampled intravenous glucose tolerance test (FSIGT.) Iron deficiency was defined as sTfR level>8.3 mg/L. Vitamin D deficiency was defined as 25(OH)D level<20 ng/mL. Linear regression was used to measure the associations of, and interaction between, 25(OH)D and sTfR with IL-6 and insulin sensitivity.Results: The prevalence of vitamin D deficiency was 37% in obese vs. 10% in lean subjects. STfR was negatively associated with Si (p<0.01) and positively associated with IL-6 (p<0.0001). 25(OH)D trended toward a positive association with Si (p=0.08) and was negatively associated with IL-6 (p<0.01). There was no interaction between sTfR and 25(OH)D in the associations with either Si or IL-6.Conclusions: Higher vitamin D levels and better iron status are associated with increased insulin sensitivity and decreased inflammation in our small cohort. Micronutrient modulation may have a future role in dietary interventions for the prevention of insulin resistance and complications of chronic inflammation.

مستند نام اشخاص تاييد نشده

King, Emily Clark

مستند نام اشخاص تاييد نشده

Elashoff, Robert M

مستند نام تنالگان تاييد نشده

UCLA

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y