عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL11t5w9pt
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Characterization of the archaebacterial ortholog of the processing body subunit Winnebago/Growl
نام عام مواد
[Thesis]
نام نخستين پديدآور
Motamedi, Amir
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
UC San Diego
تاریخ نشرو بخش و غیره
2010
یادداشتهای مربوط به پایان نامه ها
کسي که مدرک را اعطا کرده
UC San Diego
امتياز متن
2010
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Because the transcriptional machinery is inactive throughout late stages of oogenesis and early stages of embryogenesis, the initial development of the embryo is driven by post-transcriptional regulation of maternally deposited mRNA. In Drosophila, this post-transcriptional regulation occurs at specialized sites called P- bodies. While P bodies contain proteins required for mRNA degradation, translational control, and microRNA processing, the complete composition of the P body is unknown. Recent work on the biochemistry of the P body has identified a novel protein of unknown function called Winnebago. Winnebago contains an atypical conserved ATPase motif homologous with the cyclo-ligase human methenyltetrahydrofolate synthetase (MTHFS) and a conserved RNA recognition motif suggesting that Winnebago may be a novel RNA modifying enzyme. Consistent with this, the substrate binding site of the Winnebago and its archaebacterial homologs are not conserved with the human MTHFS, indicating that Winnebago has a unique class of substrate. In this study, Swinn, the Winnebago homolog from Sulfolobus, was purified and it was demonstrated that it is an ATPase. We also found that Swinn does not use the normal substrates of MTHFS, arguing that it acts on a novel class of cyclo-ligase substrates. This work lays the groundwork for future studies to identify the substrate of the Winnebago family of ATPases and their role in RNA regulation
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Motamedi, Amir
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
UC San Diego
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
