عنوان

Interfacial phenomena in drug delivery and targeting /

شابک

1420022628

شابک

9781420022629

شابک اشتباه

9783718656332

عنوان اصلي

Interfacial phenomena in drug delivery and targeting /

نام عام مواد

[Book]

نام نخستين پديدآور

by G. Buckton.

محل نشرو پخش و غیره

Boca Raton :

نام ناشر، پخش کننده و غيره

CRC Press,

تاریخ نشرو بخش و غیره

2018.

نام خاص و کميت اثر

1 online resource :

ساير جزييات

illustrations

عنوان فروست

Drug Targeting and Delivery ;

مشخصه جلد

volume 5

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface to The Series -- Introduction -- List of Symbols -- PART A FUNDAMENTALS -- Chapter 1: Interfacial Phenomena, Surface Tension and Liquid/Liquid Interfaces -- 1.1 Surfaces and interfaces -- 1.2 The liquid/vapour interface -- 1.2.1 The measurement of surface tension -- 1.2.2 The effect of additives on surface tension -- 1.2.3 Foams -- 1.2.4 Concluding comments on the liquid/vapour interface -- 1.3 The liquid/liquid interface -- 1.3.1 Studies on insoluble monolayers -- 1.3.2 Emulsions -- 1.3.2.1 The basic concepts -- 1.3.2.2 Emulsion stability -- 1.3.2.3 Phases and stabilisers -- 1.3.3 Concluding comments on liquid/liquid interfaces -- 1.4 The properties of water -- Chapter 2: The Solid/Liquid Interface -- 2.1 The solid surface -- 2.1.1 Solid surface tension and solid surface energy -- 2.2 Crystalline and amorphous materials -- 2.3 Contact angles -- 2.3.1 The wetting process -- 2.3.2 Factors which affect contact angle -- 2.4 Measurement of contact angles -- 2.4.1 Contact angles on smooth flat surfaces -- 2.4.2 Capillary penetration -- 2.4.3 Measurement of contact angles for powdered systems -- 2.4.3.1 The difficulties with powders -- 2.4.3.2 Contact angles on compacts -- 2.4.3.3 Liquid penetration experiments -- 2.4.4 Comparison of contact angle values obtained from different techniques -- 2.5 Estimation of surface energy values for solids -- 2.5.1 Critical surface tension, yc -- 2.5.2 Polar and dispersion components of surface energy -- 2.5.2.1 The nature of interfacial forces -- 2.5.2.2 Calculation of polar and dispersion forces -- 2.5.3 Theory of non-additive surface energy components -- 2.5.3.1 Calculation of acid-base surface energy parameters -- 2.5.4 Equation of state approaches -- 2.6 Estimating surface energies by use of immersional calorimetry.

متن يادداشت

2.7 Adsorption at the solid/liquid interface -- 2.7.1 Isotherms for the adsorption of solute onto solid from solution -- 2.7.2 Factors which affect the extent of adsorption from solution -- 2.7.3 Significance of adsorption at the solid/liquid interface -- Chapter 3: The Solid/Vapour Interface -- 3.1 The basis of adsorption -- 3.2 Clean surfaces -- 3.3 Solid/vapour adsorption isotherms -- 3.3.1 The Langmuir isotherm -- 3.3.2 Type II, III, IV and V physical isotherms -- 3.3.3 Freudlich isotherm -- 3.3.4 Brunauer, Emmett and Teller Isotherm -- 3.3.5 GAB isotherm -- 3.3.6 Polanyi adsorption potential -- 3.4 Capillary condensation -- 3.5 Thermodynamics of adsorption -- 3.5.1 Isosteric studies -- 3.5.2 Calorimetric studies -- 3.5.2.1 An introduction to isothermal microcalorimetry -- 3.6 Interactions between powders and water vapour -- 3.6.1 Water adsorption -- 3.6.2 Water absorption -- 3.6.3 Transfer of water between solids -- 3.6.4 Deliquescence -- 3.6.5 Hydrates -- 3.7 Reverse phase chromatography -- 3.7.1 Adsorption parameters at zero coverage -- 3.7.2 Adsorption isotherms -- Chapter 4: Other Interfacial Phenomena -- 4.1 Solid/solid interfaces -- 4.1.1 Friction -- 4.1.2 Lubrication -- 4.1.3 Adhesion -- 4.2 Aerosols -- 4.2.1 Formation of aerosols -- 4.3 Relationships between interfacial phenomena and other properties -- 4.3.1 Tensile strength -- 4.3.2 Solubility parameter -- 4.4 Electrical aspects of interfaces -- 4.4.1 Sources of charge on materials -- 4.4.2 DLVO theory -- 4.5 Some relationships between interfacial phenomena -- Chapter 5: Surfactants -- 5.1 Types of surfactant -- 5.2 Micelles and surfactant aggregation -- 5.2.1 Micelle formation -- 5.2.2 Determination of the CMC -- 5.2.3 Factors affecting the CMC -- 5.2.4 Other phase behaviour -- 5.2.4.1 Conformation below the CMC -- 5.2.4.2 Cloud point and gel formation -- 5.3 Properties of surfactants.

متن يادداشت

5.3.1 Wetting agents -- 5.3.2 Detergency -- 5.3.3 Solubilisation -- 5.4 Surfactants as stabilisers of emulsions and suspensions -- 5.4.1 Emulsions -- 5.4.2 Microemulsions -- 5.4.3 Emulsion stability -- 5.4.3.1 HLB system -- 5.4.3.2 Other stability aspects -- 5.5 Surfactants as stabilisers of suspensions -- 5.6 Nonionic surfactant vesicles -- 5.7 Natural surfactants -- 5.7.1 In the gastrointestinal tract (bile salts) -- 5.7.2 In the lung and eye -- 5.8 Surfactant toxicity -- PART B : PRACTICAL APPLICATIONS -INTERFACIAL PHENOMENA IN PRODUCT DEVELOPMENT AND IN USE -- Chapter 6: Development Aspects -- 6.1 Introduction -- 6.2 Surface energetic considerations in the development of solid dosage forms -- 6.2.1 Mixing and excipient interactions -- 6.2.2 Spreading of binders during wet granulation -- 6.2.3 Adhesion of film coatings to tablets -- 6.2.4 Drug/drug and drug/carrier interactions in dry powder inhalers -- 6.3 Surface energetic considerations in the development of other dosage forms -- 6.3.1 Non-aqueous suspensions (inhalation aerosols) -- 6.3.1.1 Dispersion of solids to form suspensions -- 6.3.1.2 Aggregation of particles in metered dose inhalers -- 6.3.1.3 Adhesion to container walls -- 6.3.2 Aqueous suspensions -- 6.3.3 Packaging -- 6.4 Variability of surfaces -- 6.4.1 Comminution -- 6.4.2 Spray drying -- 6.4.3 Freeze drying -- 6.4.4 Mixing -- 6.4.5 Concluding comments: optimising surfaces for ideal properties. -- Chapter 7: Wettability, Solubility, Dissolution, Partition and Absorption -- 7.1 Introduction -- 7.2 Wettability and solubility -- 7.1.1 Considerations of how aspects of structure relate to wettability -- 7.2.2 Considerations of how aspects of structure relate to solubility -- 7.2.3 Relationships between wettability and solubility -- 7.2.4 Relationships between wettability and the rate of solution -- 7.3 Partition.

متن يادداشت

7.3.1 Relationships between wettability, solubility and partition coefficient2 -- 7.3.2 Water dragging effects -- 7.3.3 Choice of solvent and the Collander equation -- 7.4 Absorption across biological membranes -- 7.4.1 Absorption from the gastro-intestinal tract -- 7.4.1.1 General concepts -- 7.4.1.2 Particulate absorption -- 7.4.2 Concluding comments -- Chapter 8: Bioadhesion and Mucoadhesion -- 8.1 Introduction to bioadhesion and mucoadhesion -- 8.1.1 Examples of bioadhesive systems -- 8.2 Interfacial models of bioadhesion -- 8.2.1 Modelling mucoadhesion using surface energies -- 8.2.2 Interpenetration in mucoadhesion -- 8.3 Approaches to the testing of bioadhesive performance -- 8.4 Ocular inserts -- Chapter 9: Interactions of Colloidal Delivery Systems with The Biological Environment -- 9.1 Behaviour of biological components at the solid/liquid interface -- 9.1.1 Flexible polymers -- 9.1.2 Rigid polymers -- 9.1.3 Interfacial predictions of polymer adsorption -- 9.1.4 Enthalpy and entropy of protein adsorption -- 9.2 Functions of protein adsorption -- 9.3 Targeting of colloidal particles -- 9.3.1 Desirable surface properties to prevent opsonisation -- 9.4 Approaches for targeting microspheres to different body sites -- 9.5 Interactions between surfactant coated particles and plasma proteins -- 9.6 The "Stealth" liposome -- Index.

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

موضوع مستند نشده

Drug delivery systems.

موضوع مستند نشده

Drug targeting.

موضوع مستند نشده

Interfaces (Physical sciences)

موضوع مستند نشده

Drug delivery systems.

موضوع مستند نشده

Drug targeting.

موضوع مستند نشده

Interfaces (Physical sciences)

موضوع مستند نشده

MEDICAL / Pharmacology.

موضوع مستند نشده

MED-- 071000

شماره

ويراست

شماره رده

مستند نام اشخاص تاييد نشده

Buckton, G.

تاريخ عمليات

20200822182153.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y