عنوان

Microbial infections and cancer therapy /

شابک

1351041878

شابک

1351041886

شابک

1351041894

شابک

1351041908

شابک

9781351041874

شابک

9781351041881

شابک

9781351041898

شابک

9781351041904

شابک اشتباه

9789814774864

عنوان اصلي

Microbial infections and cancer therapy /

نام عام مواد

[Book]

نام نخستين پديدآور

edited by Ananda M. Chakrabarty, Arsénio M. Fialho.

محل نشرو پخش و غیره

Singapore :

نام ناشر، پخش کننده و غيره

Pan Stanford Publishing Pte. Ltd.,

تاریخ نشرو بخش و غیره

[2019]

نام خاص و کميت اثر

1 online resource

متن يادداشت

3.3.3.1 Anti-hypoxia-inducible factor 1 alpha antibody

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Cover; Half Title; Title Page; Copyright Page; Table of Contents; Preface; 1: Bifidobacterium as a Delivery System of Functional Genes for Cancer Therapy; 1.1 The Potential Superiority of Bifidobacterium as a Delivery System for Cancer Gene Therapy; 1.1.1 The Biological Features of Bifidobacterium Associated with Cancer Gene Therapy; 1.1.2 Endogenous Plasmids and Cloning Vectors in Bifidobacterium; 1.1.3 Expression Plasmids in Bifidobacterium for Cancer Gene Therapy; 1.1.3.1 Plasmid pBLES100; 1.1.3.2 Plasmid pGEX-1LamdaT; 1.1.3.3 Plasmids pBV220 and pBV22210

متن يادداشت

1.2 The Anticancer Mechanism of Bifidobacterium as an Oral Delivery System for Cancer Gene Therapy1.2.1 Oral Administration of Bifidobacterium Affects the Immune System; 1.2.2 Oral Administration of Bifidobacterium Modulates Gut Microbial Community; 1.2.3 Oral Administration of Bifidobacterium Affects Cancer Cell Signal Transduction; 1.3 The Application of Bifidobacterium as a Delivery System of Functional Genes for Cancer Therapy; 1.3.1 Bifidobacterium as a Delivery System of Functional Genes for Cancer Gene Therapy; 1.3.2 Bifidobacterium Combination with Other Fac tors for Synergy

متن يادداشت

1.3.2.1 Combination with radiation and chemotherapeutic drugs1.3.2.2 Combination with prebiotics; 1.3.2.3 Combination with trace element selenium; 1.3.3 The New Mutagenesis Strategies for Genetic Modification of Bifidobacterium; 1.3.3.1 Single-crossover plasmid insertion; 1.3.3.2 Double-crossover and double-crossover markerless gene deletion; 1.3.3.3 Homologous recombination mediated by a temperature-sensitive plasmid; 1.4 Future Prospects; 2: Therapy with Oncolytic Clostridium novyi-NT: From Mice to Men; 2.1 Targeted Therapies at the Tissue Level

متن يادداشت

2.2 Clostridia as Live Therapeutic Agents for Cancer Therapy2.3 C. novyt NT as a Live Therapeutic Agent for Cancer Therapy; 2.3.1 C. novyi; 2.3.2 C. novyi-NT; 2.4 Preclinical Studies: Toxicity Associated with C. novyi-NT Treatment; 2.5 Preclinical Studies: Therapeutic Effects; 2.6 Preclinical Studies: Combination Approaches for Optimized Efficacy; 2.7 From Bench to Bedside; 2.8 Clinical Studies: Canine Trial; 2.9 Clinical Studies: Phase I Human Trial; 2.10 Summaiy and Future Perspectives; 3: Genetic Engineering of Clostridial Strains for Cancer Therapy

متن يادداشت

3.1 Tumor Hypoxia and Necrosis: A Blessing in Disguise?3.2 Clostridia as Cancer-Fighting Agents; 3.2.1 Embodiment of Treatment; 3.2.1.1 Administration route and form; 3.2.1.2 Tumor colonization; 3.2.1.3 Mechanism of action; 3.2.1.4 Termination of treatment; 3.2.2 Limitations of Clostridial Oncolysis; 3.3 Genetic Engineering Approaches; 3.3.1 The Underpinning Science; 3.3.1.1 Genetic tools; 3.3.1.2 Strain selection; 3.3.2 Clostridial-Directed Enzyme Prodrug Therapy; 3.3.2.1 Cytosine deaminase; 3.3.2.2 Nitroreductases; 3.3.2.3 Carboxypeptidase G2; 3.3.3 Clostridial-Directed Antibody Therapy

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

متن يادداشت

This book deals with the emerging concept that certain pathogenic bacteria and viruses, when infecting people with cancer, actively fight tumors, allowing their regression. Although such observations go back more than 100 years, use of specific bacterial strains, or viruses, usually genetically modified with known anticancer drugs, and their protein/peptide products, has gained ground in recent years, allowing significant cancer regression in clinical trials with stage III/IV cancer patients or even in pediatric brain tumor patients, often without any demonstration of toxicity. It is composed of 12 chapters written by pioneers in microbial, biotech, and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies. Such combinatorial therapies have gained particular attention as a strategy to overcome drug resistance, and the readers of the book will discover their impact on fundamental research and promising results from clinical trials.

منبع سفارش / آدرس اشتراک

Ingram Content Group

شماره انبار

9781351041881

عنوان

Microbial Infections and Cancer Therapy.

شماره استاندارد بين المللي کتاب و موسيقي

9789814774864

موضوع مستند نشده

Cancer-- Treatment.

موضوع مستند نشده

Medical microbiology.

موضوع مستند نشده

Cancer-- Treatment.

موضوع مستند نشده

MEDICAL-- Biotechnology.

موضوع مستند نشده

MEDICAL-- Infectious Diseases.

موضوع مستند نشده

Medical microbiology.

موضوع مستند نشده

MEDICAL-- Pharmacology.

موضوع مستند نشده

MED-- 009000

موضوع مستند نشده

MED-- 022090

موضوع مستند نشده

MED-- 071000

موضوع مستند نشده

TCB

شماره

ويراست

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Chakrabarty, Ananda M.,1938-

مستند نام اشخاص تاييد نشده

Fialho, Arsenio

تاريخ عمليات

20200822174510.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y