Cover; Title Page; Copyright Page; PREFACE; TABLE OF CONTENTS; INTRODUCTION; Chapter 1 Basic Physical Properties of DNA; I. DNA Structure; A. Single-Stranded DNA; B. The Double Helix; C. Alternative Forms of the Double Helix; D. Other Regular Structures; E. Hairpins and Cruciform Structures; II. Flexibility of the Double Helix; A. Macromolecular Conformation in Solution; B. Chains with Correlated Direction of Adjacent Links; C. Persistence Length of DNA; D. Excluded Volume Effect; E. Torsional Rigidity of the Double Helix; III. Conformational Transitions.
متن يادداشت
A. General Properties of Conformational TransitionsB. Statistical-Mechanical Treatment of Conformational Transition; C. Helix-Coil Transitions; D. B-A Transition; E. B-Z Transition; Chapter 2 Circular DNA and Supercoiling; I. The Circular Form of DNA; A. The Discovery of Circular D N A; B. The Topological Aspect of Inter-Strand Linkage; C. Linking Number Difference and Superhelical Density: Topoisomers; II. Experimental Studies of Supercoiling; A. Determining the Linking Number Difference; B. The Dependence of Superhelical Density on Solution Conditions.
متن يادداشت
B. Theoretical Analysis of Knots and LinkagesC. Knots and Linkages in DNA; D. Topological Approach to the Study of the Mechanisms of Enzymatic Reactions; Chapter 4 Formation of Noncanonical Structures under the Impact of Negative Supercoiling; I. Experimental Methods of Analysis of Noncanonical Structures in Circular DNA; A. Methods of Localization of Structural Transitions; B. The Method of Two-Dimensional Gel Electrophoresis; II. Thermodynamic Analysis of the Formation of Noncanonical Structures; III. Cruciform Structures; IV. The Left-Handed Z-Form; V. Melting of Closed Circular DNA.
متن يادداشت
C. Superhelicity of Circular DNA Isolated from CellsD. Obtaining DNA with a Preset Superhelical Density; III. Supercoiling Energy; IV. Topoisomerases; Chapter 3 Geometry and Topology of Circular DNA; I. Ribbon Theory; A. Writhe and Twist; B. Principal Properties of Writhe; II. Conformations of Supercoiled DNA; A. Torsional Rigidity of the Double Helix; B. Computer Simulation of Supercoiling; C. Experimental Studies of Supercoiled DNA Conformations; D. Thermodynamics of Supercoiling; III. Cyclization of DNA; IV. Knotted and Linked DNA; A. Types of Knots and Linkages.
متن يادداشت
VI. The H-FormVII. The Influence of Supercoiling on the B-A Transition; VIII. Statistical-Mechanical Analysis; IX. Mutual Influence and Competition of Different Structural Transitions; X. Kinetics of the Formation of Noncanonical Structures in Circular DNA; Chapter 5 The Use of Circular DNA in Studies of the Double Helix and Its General Properties; I. Finding the Helical Repeat of the Double Helix; II. Finding the Double Helix Unwinding Angle upon Ligand Binding; Chapter 6 DNA Supercoiling Inside the Cell; I. Superhelical Stress; II. The Existence of Noncanonical Structures within a Cell.
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یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
"Topology and Physics of Circular DNA presents comprehensive coverage of the physical properties of circular DNA. The author examines how topological constraints arising from cyclization of DNA lead to distinctive properties that make closed molecules radically different from linear DNA. The phenomenon of supercoiling, its geometric and topological analysis, and the formation of noncanonical structures in circular DNA under the influence of supercoiling are emphasized. The combination of consistent theoretical analysis and detailed treatment of major experimental approaches make Topology and Physics of Circular DNA an important reference volume for biophysicists, biochemists, molecular biologists, and researchers and students who want to expand their understanding of circular DNA."--Provided by publisher.
یادداشتهای مربوط به سفارشات
منبع سفارش / آدرس اشتراک
Ingram Content Group
شماره انبار
9781351355827
ویراست دیگر از اثر در قالب دیگر رسانه
شماره استاندارد بين المللي کتاب و موسيقي
9781351355827
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Circular DNA.
موضوع مستند نشده
Circular DNA.
موضوع مستند نشده
SCIENCE-- Life Sciences-- Biology.
مقوله موضوعی
موضوع مستند نشده
MED008000
موضوع مستند نشده
SCI-- 008000
موضوع مستند نشده
SCI029000
موضوع مستند نشده
SCI049000
رده بندی ديویی
شماره
574
.
87/3282
ويراست
20
رده بندی کنگره
شماره رده
QP624
.
5
.
C57
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )