عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TLets794350
عنوان و نام پديدآور
عنوان اصلي
Fluorescence probes for the detection of biologically relevant species
نام عام مواد
[Thesis]
نام نخستين پديدآور
Gardiner, Jordan
نام ساير پديدآوران
James, Tony ; Van Den Elsen, Johannes
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of Bath
تاریخ نشرو بخش و غیره
2019
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Thesis (Ph.D.)
امتياز متن
2019
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Detection of chemical species in physiological systems is of great importance in the research and investigation of human diseases. Fluorescence spectroscopy has proven itself as an essential tool for the study of targets in biological systems. It is a reliable method for the semi-quantitative analysis of target analytes and provides a near unprecedented level of spatial and temporal resolution. As such, there is a need for increased specificity and new modes of detection within the field of fluorescent probes which drives research and development in the area. An introduction to the background of fluorescence is given herein, with explanations of the common mechanisms of fluorescence. Then, analytes that are commonly targeted for detection and probes that have been designed to target them are exemplified. Three research chapters follow, describing the design, synthesis and analysis of new probes developed throughout this thesis. Coumarin, fluorescein and TCF fluorophores are used ascore units in each of the chapters formed. Probes that have been developed include MLGsfor dual analyte "AND" detection, that require the presence of two species for a signal tobe released. A coumarin-based triple analyte "AND" probe has also been developed thatrequired the presence of Glutamate, Zinc2+ and peroxynitrite (ONOO-), which has thepotential to detect diseased neurons in the brain. Single analyte TCF-based probes havealso been developed for the detection of ONOO and glutathione. A number of theseprobes have been studied in cellular systems and show great promise for use in the study ofhuman disease and revealing important information between the relationships of chemicals therein.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Fluorescent Probes ; Molecular Logic Gates
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Gardiner, Jordan
نام شخص - ( مسئولیت معنوی درجه دوم )
مستند نام اشخاص تاييد نشده
James, Tony ; Van Den Elsen, Johannes
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
University of Bath
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
