عنوان

Mathematical modelling of solid tumour growth :

شماره

TLets763471

عنوان اصلي

Mathematical modelling of solid tumour growth :

نام عام مواد

[Thesis]

نام نخستين پديدآور

Al-Saedi, Hayder M.

عنوان اصلي به قلم نويسنده ديگر

a Dynamical Density Functional Theory-based model

نام ناشر، پخش کننده و غيره

Loughborough University

تاریخ نشرو بخش و غیره

2018

جزئيات پايان نامه و نوع درجه آن

Thesis (Ph.D.)

امتياز متن

2018

متن يادداشت

We present a theoretical framework based on an extension of Dynamical Density Functional Theory (DDFT) to describe the structure and dynamics of cells in living tissues and tumours. DDFT is a microscopic statistical mechanical theory for the time evolution of the density distribution of interacting many-particle systems. The theory accounts for cell pair-interactions, different cell types, phenotypes and cell birth and death processes (including cell division), in order to provide a biophysically consistent description of processes bridging across the scales, including the description of the tissue structure down to the level of the individual cells. Analysis of the model is presented for a single species and a two-species cases, the latter describing competition between a cancerous and healthy cells. In suitable parameter regimes, model results are consistent with biological observations. Of particular note, divergent tumour growth behaviour, mirroring metastatic and benign growth characteristics, are shown to be dependent on the cell pair-interaction parameters.

موضوع مستند نشده

Dynamical Density Functional Theory ; Tumour growth ; Cell-cell interactions

مستند نام اشخاص تاييد نشده

Al-Saedi, Hayder M.

مستند نام تنالگان تاييد نشده

Loughborough University

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y